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Literature summary for 1.14.14.104 extracted from

  • Falkenhagen, H.; Stoeckigt, J.
    Enzymic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalyzed by a novel cytochrome P450-dependent enzyme from plant cell cultures of Rauwolfia serpentina (1995), Z. Naturforsch. C, 50, 45-53.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
CO
-
Rauvolfia serpentina
cytochrome c
-
Rauvolfia serpentina
ketoconazole
-
Rauvolfia serpentina

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
26
-
vinorine
-
Rauvolfia serpentina

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vinorine + [reduced NADPH-hemoprotein reductase] + O2 Rauvolfia serpentina enzyme is involved in the biosynthesis of the alkaloid ajmaline vomilenine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rauvolfia serpentina
-
-
-

Storage Stability

Storage Stability Organism
-28°C, 20% sucrose, no loss of activity Rauvolfia serpentina

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vinorine + [reduced NADPH-hemoprotein reductase] + O2
-
Rauvolfia serpentina vomilenine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
vinorine + [reduced NADPH-hemoprotein reductase] + O2 enzyme is involved in the biosynthesis of the alkaloid ajmaline Rauvolfia serpentina vomilenine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Rauvolfia serpentina

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
-
Rauvolfia serpentina

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450
-
Rauvolfia serpentina