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Literature summary for 1.14.14.106 extracted from

  • Wheeler, A.L.; Long, R.M.; Ketchum, R.E.B.; Rithner, C.D.; Williams, R.M.; Croteau, R.
    Taxol biosynthesis: differential transformations of taxadien-5alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells (2001), Arch. Biochem. Biophys., 390, 265-278.
    View publication on PubMed
Search for more literature for 1.14.14.106

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 taxa-4(20),11-dien-5alpha-ol
-
 Taxus cuspidata
0.024
-
 taxa-4(20),11-dien-5alpha-yl-acetate
-
 Taxus cuspidata

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Taxus cuspidata
-
-

Organism

Organism UniProt Comment Textmining
Taxus cuspidata
-
 yew
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Taxus cuspidata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
taxa-4(20),11-dien-5alpha-ol + [reduced NADPH-hemoprotein reductase] + O2
-
 Taxus cuspidata taxa-4(20),11-dien-5alpha,13alpha-diol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
taxa-4(20),11-dien-5alpha-yl-acetate + [reduced NADPH-hemoprotein reductase] + O2
-
 Taxus cuspidata taxa-4(20),11-dien-5alpha,13alpha-diol-5-acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
 Taxus cuspidata

pH Range

pH Minimum pH Maximum Comment Organism
6.2 8.2 half-maximal activity at pH 6.2 and pH 8.2 Taxus cuspidata