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Literature summary for 1.14.14.106 extracted from
- Taxol biosynthesis: taxane 13alpha-hydroxylase is a cytochrome P450-dependent monooxygenase (2001), Proc. Natl. Acad. Sci. USA, 98, 13595-13600.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| heterologous expression in Sf9 insect cells | Taxus cuspidata |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.014 | - |
taxa-4(20),11-dien-5alpha-ol | - |
Taxus cuspidata |  |
| 0.024 | - |
taxa-4(20),11-dien-5alpha-yl-acetate | - |
Taxus cuspidata | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Taxus cuspidata | Q8W4T9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Taxus cuspidata | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| taxa-4(20),11-dien-5alpha-ol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Taxus cuspidata | taxa-4(20),11-dien-5alpha,13alpha-diol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| taxa-4(20),11-dien-5alpha-yl-acetate + [reduced NADPH-hemoprotein reductase] + O2 | 6% of activity with taxa-4(20),11-dien-5alpha-ol | Taxus cuspidata | taxa-4(20),11-dien-5alpha,13alpha-diol-5-acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Taxus cuspidata |
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Release 2023.1 (January 2023)
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