BRENDA - Enzyme Database show
show all sequences of 1.14.14.127

Insulin receptor-mediated nutritional signalling regulates juvenile hormone biosynthesis and vitellogenin production in the German cockroach

Abrisqueta, M.; Sueren-Castillo, S.; Maestro, J.L.; Insect Biochem. Mol. Biol. 49, 14-23 (2014)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Blattella germanica
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Blattella germanica
D6CJJ9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
corpus allatum
-
Blattella germanica
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
745073
Blattella germanica
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Blattella germanica
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Blattella germanica
Cloned(Commentary) (protein specific)
Commentary
Organism
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Blattella germanica
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Blattella germanica
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Blattella germanica
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
corpus allatum
-
Blattella germanica
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
745073
Blattella germanica
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Expression
Organism
Commentary
Expression
Blattella germanica
starving reduces the enzyme expression
down
General Information
General Information
Commentary
Organism
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
General Information (protein specific)
General Information
Commentary
Organism
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
Expression (protein specific)
Organism
Commentary
Expression
Blattella germanica
starving reduces the enzyme expression
down
Other publictions for EC 1.14.14.127
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745508
Cardoso-Junior
Methyl farnesoate epoxidase ( ...
Melipona scutellaris
J. Insect Physiol.
101
185-194
2017
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1
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-
-
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1
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11
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7
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1
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2
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1
2
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1
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7
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1
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-
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1
1
-
-
-
746473
Jiang
Characterization of juvenile ...
Epicauta chinensis
Sci. Rep.
7
2308
2017
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-
1
-
1
-
-
-
1
-
-
1
-
3
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2
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1
1
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2
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1
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1
2
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1
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1
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1
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2
-
-
1
1
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-
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-
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1
-
2
2
-
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-
744987
Jedlicka
Gene expression dynamics in m ...
Bombus terrestris terrestris
Front. Physiol.
7
574
2016
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1
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1
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2
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10
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1
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1
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1
1
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1
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10
-
-
1
-
-
-
-
-
-
-
-
-
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2
2
-
-
-
732291
Minakuchi
Expressional and functional an ...
Tribolium castaneum
J. Insect Physiol.
80
61-70
2015
-
-
1
-
-
-
-
-
-
-
-
-
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3
-
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3
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2
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1
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3
-
-
2
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-
-
-
-
-
-
-
-
-
1
1
-
-
-
745073
Abrisqueta
Insulin receptor-mediated nut ...
Blattella germanica
Insect Biochem. Mol. Biol.
49
14-23
2014
-
-
1
-
-
-
-
-
-
-
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1
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3
-
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1
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1
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2
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1
2
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1
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1
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1
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1
2
2
1
-
-
731512
Daimon
Function, diversity, and appli ...
Diploptera punctata
Biotechnol. Appl. Biochem.
60
82-91
2013
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1
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1
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1
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1
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732805
Helvig
CYP15A1, the cytochrome P450 t ...
Diploptera punctata
Proc. Natl. Acad. Sci. USA
101
4024-4029
2004
-
1
1
-
-
-
4
1
-
-
1
1
-
5
-
-
1
-
-
4
-
-
4
1
1
-
-
1
1
-
-
1
-
-
3
-
1
1
1
-
-
-
3
4
-
1
-
-
1
1
-
-
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1
-
4
-
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4
1
1
-
-
1
1
-
-
-
-
-
-
-
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-
731914
Andersen
Photoaffinity labeling of meth ...
Diploptera punctata
Insect Biochem. Mol. Biol.
25
713-719
1995
-
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-
-
-
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2
-
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1
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4
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5
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1
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2
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2
2
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1
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5
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1
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731921
Pratt
-
The influence of a P450 inhibi ...
Periplaneta americana
Insect Biochem.
14
609-614
1984
-
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1
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-
731740
Feyereisen
Enzymic synthesis of juvenile ...
Locusta migratoria
Eur. J. Biochem.
118
231-238
1981
-
-
-
-
-
-
3
1
1
-
-
-
-
3
-
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2
-
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1
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3
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1
1
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2
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1
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