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Literature summary for 1.14.14.128 extracted from

  • Daimon, T.; Kozaki, T.; Niwa, R.; Kobayashi, I.; Furuta, K.; Namiki, T.; Uchino, K.; Banno, Y.; Katsuma, S.; Tamura, T.; Mita, K.; Sezutsu, H.; Nakayama, M.; Itoyama, K.; Shimada, T.; Shinoda, T.
    Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori (2012), PLoS Genet., 8, e1002486.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf2 or Sf9 cells Bombyx mori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Bombyx mori the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Bombyx mori C0SPF7
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Source Tissue

Source Tissue Comment Organism Textmining
corpus allatum the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages Bombyx mori
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone Bombyx mori juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme exhibits at least 18fold higher activity for farnesoate than (2E,6E)-methyl farnesoate Bombyx mori juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O juvenile-hormone-III carboxylate i.e. (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate ?

Synonyms

Synonyms Comment Organism
BGIBMGA011708
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 Bombyx mori
CYP15C1
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 Bombyx mori

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a heme-thiolate protein Bombyx mori

General Information

General Information Comment Organism
malfunction CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1 Bombyx mori
metabolism the enzyme is involved in the synthesis of juvenile hormone Bombyx mori