BRENDA - Enzyme Database show
show all sequences of 1.14.14.128

Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori

Daimon, T.; Kozaki, T.; Niwa, R.; Kobayashi, I.; Furuta, K.; Namiki, T.; Uchino, K.; Banno, Y.; Katsuma, S.; Tamura, T.; Mita, K.; Sezutsu, H.; Nakayama, M.; Itoyama, K.; Shimada, T.; Shinoda, T.; PLoS Genet. 8, e1002486 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Sf2 or Sf9 cells
Bombyx mori
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Bombyx mori
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bombyx mori
C0SPF7
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
corpus allatum
the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages
Bombyx mori
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
732671
Bombyx mori
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme exhibits at least 18fold higher activity for farnesoate than (2E,6E)-methyl farnesoate
732671
Bombyx mori
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
juvenile-hormone-III carboxylate i.e. (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P-450
a heme-thiolate protein
Bombyx mori
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Sf2 or Sf9 cells
Bombyx mori
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P-450
a heme-thiolate protein
Bombyx mori
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Bombyx mori
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
corpus allatum
the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages
Bombyx mori
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone
732671
Bombyx mori
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme exhibits at least 18fold higher activity for farnesoate than (2E,6E)-methyl farnesoate
732671
Bombyx mori
juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
juvenile-hormone-III carboxylate i.e. (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate
-
-
?
General Information
General Information
Commentary
Organism
malfunction
CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1
Bombyx mori
metabolism
the enzyme is involved in the synthesis of juvenile hormone
Bombyx mori
General Information (protein specific)
General Information
Commentary
Organism
malfunction
CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1
Bombyx mori
metabolism
the enzyme is involved in the synthesis of juvenile hormone
Bombyx mori
Other publictions for EC 1.14.14.128
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731512
Daimon
Function, diversity, and appli ...
Bombyx mori
Biotechnol. Appl. Biochem.
60
82-91
2013
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732671
Daimon
Precocious metamorphosis in th ...
Bombyx mori
PLoS Genet.
8
e1002486
2012
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