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show all sequences of 1.14.14.138

STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase

Subramanian, A.; Wang, J.; Gil, G.; Nucleic Acids Res. 26, 2173-2178 (1998)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
Mesocricetus auratus
the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mesocricetus auratus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
male-specific enzyme. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene
Mesocricetus auratus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
-
660023
Mesocricetus auratus
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
660023
Mesocricetus auratus
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Mesocricetus auratus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Mesocricetus auratus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
Mesocricetus auratus
the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
male-specific enzyme. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene
Mesocricetus auratus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
-
660023
Mesocricetus auratus
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
660023
Mesocricetus auratus
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.138
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
660023
Subramanian
STAT 5 and NF-Y are involved i ...
Mesocricetus auratus
Nucleic Acids Res.
26
2173-2178
1998
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659931
Subramanian
A STAT factor mediates the sex ...
Mesocricetus auratus
Mol. Cell. Biol.
15
4672-4682
1995
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657797
Chang
The lithocholic acid 6beta-hyd ...
Mesocricetus auratus
Biochem. J.
291
429-433
1993
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657795
Zimniak
Distinct forms of cytochrome P ...
Rattus norvegicus
Biochem. J.
275
105-111
1991
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659121
Teixeira
Cloning, expression, and regul ...
Mesocricetus auratus
J. Biol. Chem.
266
21030-21036
1991
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659113
Björkhem
Hydroxylations of bile acids b ...
Rattus norvegicus
J. Biol. Chem.
249
6439-6445
1974
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