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Literature summary for 1.14.14.139 extracted from
- Effect of streptozotocin-induced diabetes on the activity of 7alpha-hydroxy-4-cholesten-3-one-specific 12alpha-hydroxylase in rats (1988), Biol. Chem. Hoppe-Seyler, 369, 1117-1120.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 | Rattus norvegicus | key enzyme for the formation of cholic acid | 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | activity in diabetic group is about half of the activity in the normal group | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 | - |
Rattus norvegicus | 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O | - |
? | |
| 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 | key enzyme for the formation of cholic acid | Rattus norvegicus | 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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