Literature summary for 1.14.14.139 extracted from

Murphy, C.; Parini, P.; Wang, J.; Bjoerkhem, I.; Eggertsen, G.; Gafvels, M.
Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice (2005), Biochim. Biophys. Acta, 1735, 167-175.

Search for more literature for 1.14.14.139

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of male CYP8B1 knockout mice, the mutant mice show increased cholesterol synthesis with normal diet, and decreased cholesterol absorption under cholesterol diet and feeding of cholic acid, they accumulate less cholesteryl esters compared to wild-type mice, phenotype, overview	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cholic acid suppresses expression of CYP8B1	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	Mus musculus	dietary cholsterol and cholic acid have an influence of enzyme regulation	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male C75B1/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	-	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	dietary cholsterol and cholic acid have an influence of enzyme regulation	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP8B1	-	Mus musculus
sterol 12alpha-hydroxylase	-	Mus musculus

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Release 2023.1 (January 2023)