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Literature summary for 1.14.14.139 extracted from

  • Li, Y.; Mezei, O.; Shay, N.F.
    Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones (2007), J. Nutr., 137, 1705-1712.
    View publication on PubMed
Search for more literature for 1.14.14.139

Activating Compound

Activating Compound Comment Organism Structure
additional information hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, in both female and male mice, intake of soy isoflavones plus fenofibrate does not increase CYP8B1 mRNA levels in females, whereas there was an obvious upregulation in males, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview Mus musculus
additional information hepatocyte nuclear factor 4a strongly induces the enzyme, the enzyme expression is induced by soybean isoflavones, e.g. genistein, daidzein, and glycitein, presence of PPARa inhibits isoflavone upregulation of CYP8B1 in cotransfected HepG2 cells, mechanism modeling, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells Mus musculus
expression analysis in response to soy bean isoflavones, transient expression in Hep-G2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor Homo sapiens
additional information the enzyme expression is suppressed by cholesterol, bile acids, and insulin via activation of small heterodimer partner, a universal repressor, by ligand-bound farnesoid x receptor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information Mus musculus CYP8B1 is reportedly regulated by PPARalpha, overview ?
-
 ?
additional information Homo sapiens CYP8B1 is reportedly regulated by PPARalpha, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Mus musculus
-
hepatocyte primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information CYP8B1 is reportedly regulated by PPARalpha, overview Mus musculus ?
-
 ?
additional information CYP8B1 is reportedly regulated by PPARalpha, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
12-alpha-hydroxylase
-
 Mus musculus
12-alpha-hydroxylase
-
 Homo sapiens
CYP8B1
-
 Mus musculus
CYP8B1
-
 Homo sapiens