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Literature summary for 1.14.14.139 extracted from

  • Liu, Y.; Havinga, R.; VAN DER Leij, F.R.; Boverhof, R.; Sauer, P.J.; Kuipers, F.; Stellaard, F.
    Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics (2008), Pediatr. Res., 63, 375-381.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Rattus norvegicus
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 pregnant Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
CYP8B1
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 Rattus norvegicus
sterol 12alpha-hydroxylase
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus neonatal dexamethasone administration disturbs development of gene expression pattern into adulthood, the ratio of Cyp7a1/Cyp8b1 mRNA level, which is markedly increased at 4 weeks of age in the control group, shows a delayed increase at 8 weeks of age in the dexamethasone-treated animals down
Rattus norvegicus dexomethasone acutely induces hepatic mRNA levels of cholesterol 7alpha-hydrol Cyp6a1, cholesterol 27-hydrolase Cyp27, and in particular sterol 12alpha-hydrolase Cyp8b1. Neonatal dexomethasone administration leads to increased biliary lipid secretion, decreased Cyp8b1 mRNA expression and a 3fold higher Cyp7a1/Cyp8b1 mRNA ratio in rats at week 8 up
Rattus norvegicus dexamethasone administration results in significantly increased hepatic gene expression of Cyp8B1 in 2 days old rats compared with age-matched controls. In control animals, hepatic Cyp8b1 gene expression increases from 4 weeks onward and reaches to its maximal level at about 24 weeks of age up