BRENDA - Enzyme Database show
show all sequences of 1.14.14.143

Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase

Mahmoud, S.S.; Croteau, R.B.; Proc. Natl. Acad. Sci. USA 100, 14481-14486 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene mfs, expression under control of the CaMV 35S promoter in transformed peppermint plants
Mentha x piperita
Engineering
Amino acid exchange
Commentary
Organism
additional information
overexpression and cosuppression of mfs results in the respective increase or decrease in the production of menthofuran
Mentha x piperita
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mentha x piperita
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
Mentha x piperita
pathways for monoterpene biosynthesis in peppermint, overview
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
additional information
Mentha x piperita
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mentha x piperita
-
cv. Black Mitcham, gene mfs
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
-
689735
Mentha x piperita
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
pathways for monoterpene biosynthesis in peppermint, overview
689735
Mentha x piperita
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
additional information
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview
689735
Mentha x piperita
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
gene mfs, expression under control of the CaMV 35S promoter in transformed peppermint plants
Mentha x piperita
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
overexpression and cosuppression of mfs results in the respective increase or decrease in the production of menthofuran
Mentha x piperita
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mentha x piperita
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
Mentha x piperita
pathways for monoterpene biosynthesis in peppermint, overview
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
additional information
Mentha x piperita
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
-
689735
Mentha x piperita
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
pathways for monoterpene biosynthesis in peppermint, overview
689735
Mentha x piperita
(+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
additional information
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview
689735
Mentha x piperita
?
-
-
-
-
Other publictions for EC 1.14.14.143
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746129
Nazari
Physiological, biochemical an ...
Mentha x piperita
Plant Physiol. Biochem.
120
202-212
2017
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1
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1
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1
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1
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745751
Kumar
-
Development and characterizat ...
Mentha x piperita, no activity in Mentha arvensis cv. Kosi
Mol. Breed.
34
717-724
2014
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1
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3
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1
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1
1
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728548
Atsbaha Zebelo
Chrysolina herbacea modulates ...
Mentha aquatica
PLoS ONE
6
e17195
2011
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1
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6
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728665
Lange
Improving peppermint essential ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
108
16944-16949
2011
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689735
Mahmoud
Menthofuran regulates essentia ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
100
14481-14486
2003
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1
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1
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1
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3
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1
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286420
Mahmoud
Metabolic engineering of essen ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
98
8915-8920
2001
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1
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1
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3
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684661
Bertea
Demonstration that menthofuran ...
Mentha pulegium, Mentha x piperita
Arch. Biochem. Biophys.
390
279-286
2001
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1
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2
2
1
2
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7
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6
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4
1
1
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1
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4
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1
4
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2
1
2
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6
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4
1
1
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1
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