Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.150 extracted from

  • Ikezawa, N.; Goepfert, J.C.; Nguyen, D.T.; Kim, S.U.; OMaille, P.E.; Spring, O.; Ro, D.K.
    Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism (2011), J. Biol. Chem., 286, 21601-21611.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.150

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain EPY300 Helianthus annuus
expressed in Saccharomyces cerevisiae strain EPY300 Lactuca sativa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 Helianthus annuus
-
 (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 Lactuca sativa
-
 (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Helianthus annuus
-
 cultivar HA300
-
Lactuca sativa F8S1I0 cultivar Mariska
-

Source Tissue

Source Tissue Comment Organism Textmining
glandular trichome
-
 Helianthus annuus
-
glandular trichome
-
 Lactuca sativa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2
-
 Helianthus annuus (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2
-
 Lactuca sativa (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
COS
-
 Helianthus annuus
COS
-
 Lactuca sativa
CYP71BL1
-
 Helianthus annuus
CYP71BL2
-
 Lactuca sativa

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Helianthus annuus
cytochrome P450
-
 Lactuca sativa