BRENDA - Enzyme Database show
show all sequences of 1.14.14.154

Sterol 14alpha-demethylase, an abundant and essential mixed-function oxidase

Waterman, M.R.; Lepesheva, G.I.; Biochem. Biophys. Res. Commun. 338, 418-422 (2005)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Iron
the enzyme is a fusion protein with a 3Fe-4S ferredoxin
Methylococcus capsulatus
Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Mycobacterium tuberculosis
the genes are located on chromosomes 3, 7, and 13, the gene on chromosome 7 is the functional one while those on chromosomes 3 and 13 are processed pseudogenes which arise from reverse transcription of mRNA in germ cells and illegitimate recombination into the genome, CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
purified recombinant enzyme, crystal structure determination and analysis, overview
Mycobacterium tuberculosis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
membrane
-
Methylococcus capsulatus
16020
-
membrane
-
Trypanosoma brucei
16020
-
membrane
-
Homo sapiens
16020
-
soluble
-
Mycobacterium tuberculosis
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM, overview
?
-
-
?
additional information
Methylococcus capsulatus
CYP51 participates in biosynthesis of cholesterol
?
-
-
-
additional information
Homo sapiens
CYP51 plays a key role in fertilization by producing intermediates that could serve as ligands for nuclear receptors
?
-
-
-
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Acanthamoeba polyphaga
-
-
-
Homo sapiens
-
-
-
Methylococcus capsulatus
-
-
-
Mycobacterium tuberculosis
-
-
-
Trypanosoma brucei
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Leydig cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
ovary
-
Homo sapiens
-
spermatid
acrosomal membrane of elongated spermatids
Homo sapiens
-
spermatozoon
acrosomal membrane of mature sperm
Homo sapiens
-
testis
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Homo sapiens
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM, overview
671727
Homo sapiens
?
-
-
-
?
additional information
CYP51 participates in biosynthesis of cholesterol
671727
Methylococcus capsulatus
?
-
-
-
-
additional information
CYP51 plays a key role in fertilization by producing intermediates that could serve as ligands for nuclear receptors
671727
Homo sapiens
?
-
-
-
-
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
Ferredoxin
enzyme-bound, the enzyme is a fusion protein with a 3Fe-4S ferredoxin
Methylococcus capsulatus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Iron
the enzyme is a fusion protein with a 3Fe-4S ferredoxin
Methylococcus capsulatus
Cloned(Commentary) (protein specific)
Commentary
Organism
the genes are located on chromosomes 3, 7, and 13, the gene on chromosome 7 is the functional one while those on chromosomes 3 and 13 are processed pseudogenes which arise from reverse transcription of mRNA in germ cells and illegitimate recombination into the genome, CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM
Homo sapiens
expression in Escherichia coli
Mycobacterium tuberculosis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
Ferredoxin
enzyme-bound, the enzyme is a fusion protein with a 3Fe-4S ferredoxin
Methylococcus capsulatus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
purified recombinant enzyme, crystal structure determination and analysis, overview
Mycobacterium tuberculosis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
membrane
-
Homo sapiens
16020
-
membrane
-
Methylococcus capsulatus
16020
-
membrane
-
Trypanosoma brucei
16020
-
soluble
-
Mycobacterium tuberculosis
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM, overview
?
-
-
?
additional information
Methylococcus capsulatus
CYP51 participates in biosynthesis of cholesterol
?
-
-
-
additional information
Homo sapiens
CYP51 plays a key role in fertilization by producing intermediates that could serve as ligands for nuclear receptors
?
-
-
-
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
?
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
?
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
Mycobacterium tuberculosis
-
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
Acanthamoeba polyphaga
-
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Leydig cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
ovary
-
Homo sapiens
-
spermatid
acrosomal membrane of elongated spermatids
Homo sapiens
-
spermatozoon
acrosomal membrane of mature sperm
Homo sapiens
-
testis
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Homo sapiens
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
CYP51 responds to cholesterol feedback regulation, being upregulated in sterol limiting conditions and downregulated in cholesterol rich conditions, regulation involves the sterol regulatory elements SRE in the promoter of the gene which bind sterol regulatory element binding protein, SREBP, the CYP51 promoter also contains a cAMP regulatory element, CRE, binding cAMP regulatory proteins CREB/CREM, overview
671727
Homo sapiens
?
-
-
-
?
additional information
CYP51 participates in biosynthesis of cholesterol
671727
Methylococcus capsulatus
?
-
-
-
-
additional information
CYP51 plays a key role in fertilization by producing intermediates that could serve as ligands for nuclear receptors
671727
Homo sapiens
?
-
-
-
-
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
?
-
-
-
?
norlanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
?
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Mycobacterium tuberculosis
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
671727
Acanthamoeba polyphaga
4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.154
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744274
Park
Nitric oxide stimulates cellu ...
Homo sapiens
Biochem. J.
474
3241-3252
2017
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
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1
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-
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1
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-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
744843
Emami
An overview of azoles targeti ...
Leishmania infantum, Leishmania major, Leishmania mexicana
Eur. J. Med. Chem.
135
241-259
2017
-
6
-
-
-
-
39
-
-
-
-
-
-
3
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
-
-
-
-
-
4
-
6
-
-
-
-
-
4
39
-
-
-
-
-
-
-
-
-
-
-
6
-
-
6
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
744860
Borcea
-
Synthesis and molecular docki ...
Candida albicans SC5314
Farmacia
65
683-689
2017
-
-
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745117
Stana
Design, synthesis and antifun ...
Candida albicans SC5314
Int. J. Mol. Sci.
18
E177
2017
-
2
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745378
Hargrove
Structural analyses of Candid ...
Candida albicans
J. Biol. Chem.
292
6728-6743
2017
-
-
1
1
-
-
8
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
8
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
745682
Alvarez-Rueda
The amino acid substitution N ...
Candida albicans
Med. Mycol.
54
764-775
2016
-
-
1
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746216
Tyndall
Structural and functional elu ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae YJM789
PLoS ONE
11
e0167485
2016
-
-
1
1
2
-
7
-
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
7
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746454
Warrilow
Azole antifungal sensitivity ...
Malassezia globosa, Malassezia globosa CBS 7966
Sci. Rep.
6
27690
2016
-
-
1
-
-
-
4
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
6
-
1
-
-
3
1
-
-
-
-
-
4
-
-
1
-
-
-
-
4
4
-
3
-
-
-
-
-
-
-
1
-
-
-
-
6
-
1
-
-
3
1
-
-
-
-
-
-
-
3
3
728050
Emami
Imidazolylchromanones containi ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Enzyme Inhib. Med. Chem.
29
263-271
2014
-
-
-
1
-
-
7
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
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7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744385
Morrison
Identification, modeling and ...
Danio rerio
Biochim. Biophys. Acta
1840
1825-1836
2014
-
-
1
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
745522
Friggeri
Structural basis for rational ...
Trypanosoma cruzi, Trypanosoma cruzi CL Brener
J. Med. Chem.
57
6704-6717
2014
-
2
1
1
-
-
2
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
-
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-
1
-
-
-
-
2
1
1
1
-
-
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2
-
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-
-
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1
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-
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2
-
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-
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-
-
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-
726714
Cools
Impact of recently emerged ste ...
Zymoseptoria tritici
Appl. Environ. Microbiol.
77
3830-3837
2011
-
-
1
-
7
-
6
-
-
-
-
-
-
5
-
-
-
-
-
-
-
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Heterologous expression and ch ...
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Molecular modeling of human la ...
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Amino acid substitutions at th ...
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1
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6
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Complementation of a Saccharom ...
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Cools
Heterologous expression of mut ...
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Petushkova
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A fluorometric method for dete ...
Mycobacterium tuberculosis
Biochemistry (Moscow) Suppl. B
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1
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1
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2
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1
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Cloning and characterization o ...
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1
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2
1
1
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1
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Lepesheva
Structural insights into inhib ...
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Sheng
Three-dimensional model of lan ...
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1
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1
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6
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1
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702515
Kitahama
The construction and character ...
Saccharomyces cerevisiae
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1
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1
3
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1
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1
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1
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-
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702576
Ming
Organocatalytic synthesis and ...
Penicillium digitatum
Bioorg. Med. Chem. Lett.
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2009
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1
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20
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1
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1
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1
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1
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1
1
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20
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1
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1
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703550
Chai
Design, synthesis, and biologi ...
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705030
Konkle
Indomethacin amides as a novel ...
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Sen
Molecular oxygen activation an ...
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1
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Yang
Expression and homology modell ...
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1
1
1
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5
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1
1
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-
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684580
Luo
The cytochrome P450 lanosterol ...
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1
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1
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1
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1
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1
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1
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1
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684925
Seliskar
Expression of microsomal lanos ...
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1
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1
1
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1
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1
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1
1
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1
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1
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4
2
2
1
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1
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2
1
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1
1
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1
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685534
Korosec
Novel cholesterol biosynthesis ...
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1
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1
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20
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1
1
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3
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1
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4
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687710
Eddine
X-ray structure of 4,4-dihydro ...
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1
1
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1
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1
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1
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1
1
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5
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2
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4
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5
1
1
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1
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688999
Ning
3,5-cyclic adenosine monophosp ...
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1
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1
1
1
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3
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2
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701584
Buckner
Sterol 14-demethylase inhibito ...
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625
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2
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701727
Parker
Differential azole antifungal ...
Homo sapiens, Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Antimicrob. Agents Chemother.
52
3597-3603
2008
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1
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16
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3
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1
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2
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3
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702509
Xu
Silencing of mouse hepatic lan ...
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Biol. Pharm. Bull.
31
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2008
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1
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4
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1
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704035
Krishnan-Natesan
Molecular characterisation of ...
Aspergillus flavus
Int. J. Antimicrob. Agents
32
519-524
2008
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1
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5
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5
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705462
Warrilow
Expression and characterizatio ...
Phanerochaete chrysosporium
Lipids
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1
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1
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1
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1
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1
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1
1
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5
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2
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1
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1
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1
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1
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1
1
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706694
Song
Expression and regulation of l ...
Mus musculus
Reprod. Fertil. Dev.
20
964-972
2008
2
-
-
-
-
-
-
-
-
-
-
-
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4
-
-
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-
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4
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-
2
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
672414
Lepesheva
Sterol 14alpha-demethylase cyt ...
Candida albicans, Homo sapiens, Methylococcus capsulatus, Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Rattus norvegicus, Saccharomyces cerevisiae, Sorghum bicolor, Trypanosoma brucei, Trypanosoma cruzi, Ustilago maydis
Biochim. Biophys. Acta
1770
467-477
2007
-
-
11
-
-
-
29
-
11
-
-
22
-
11
-
-
-
-
-
-
11
-
64
11
-
-
-
-
-
-
-
1
-
-
-
-
-
11
1
-
-
-
-
29
-
-
11
-
-
22
-
-
-
-
-
-
11
-
64
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673445
Sun
Synthesis of novel triazole de ...
Aspergillus fumigatus, Candida albicans, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans, Fonsecaea compacta, Nannizzia gypsea, Trichophyton rubrum
Eur. J. Med. Chem.
20
1-8
2007
-
-
-
-
-
-
256
-
-
-
-
-
-
18
-
-
-
-
-
-
-
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256
-
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-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684486
Podust
Small-molecule scaffolds for C ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Antimicrob. Agents Chemother.
51
3915-3923
2007
-
2
-
1
1
-
3
-
1
1
-
1
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
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2
-
1
1
1
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-
3
-
-
1
1
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685303
Shumyantseva
Electrochemical reduction of s ...
Mycobacterium tuberculosis
Biochemistry (Moscow)
72
658-663
2007
-
-
-
-
1
-
1
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
1
-
1
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-
1
-
-
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1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685453
Chen
Identification of Y118 amino a ...
Candida albicans
Biol. Pharm. Bull.
30
1246-1253
2007
-
-
1
-
3
-
1
-
1
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686798
Zhao
Expression and homology modeli ...
Penicillium digitatum
FEMS Microbiol. Lett.
277
37-43
2007
-
1
1
-
1
-
1
-
1
1
1
1
-
5
-
-
1
-
-
-
-
-
1
2
1
-
-
-
1
-
-
2
-
-
-
-
1
1
2
-
1
-
-
1
-
-
1
1
1
1
-
-
-
1
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
689083
Fraaije
A novel substitution 1381V in ...
Zymoseptoria tritici
Mol. Plant Pathol.
8
245-254
2007
-
-
-
-
3
-
4
-
-
-
-
-
-
8
-
-
-
-
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-
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3
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4
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671268
Pietila
Cloning and characterization o ...
Mycobacterium avium subsp. avium
Am. J. Respir. Cell Mol. Biol.
35
236-242
2006
-
1
1
-
-
-
5
-
-
1
-
2
-
6
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
1
1
1
-
-
-
-
5
-
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
671942
Cools
Impact of changes in the targe ...
Blumeria graminis, Candida albicans, Oculimacula acuformis, Oculimacula yallundae, Zymoseptoria tritici
Biochem. Soc. Trans.
34
1219-1222
2006
-
5
-
-
7
-
13
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
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7
-
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13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672195
McLean
Biophysical characterization o ...
Mycobacterium tuberculosis
Biochemistry
45
8427-8443
2006
-
-
1
-
-
1
7
1
-
1
-
-
-
2
-
-
1
1
-
-
-
-
3
1
-
-
1
-
1
-
-
1
-
-
-
-
-
1
1
-
-
1
-
7
-
1
-
1
-
-
-
-
-
1
-
-
-
-
3
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
672607
Zhu
Design, synthesis, and antifun ...
Aspergillus fumigatus, Candida albicans, Candida parapsilosis, Cryptococcus neoformans, Microsporum canis, Trichophyton rubrum
Bioorg. Med. Chem. Lett.
16
5285-5289
2006
-
-
-
-
-
-
48
-
-
-
-
6
-
7
-
-
-
6
-
-
-
-
12
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
48
-
-
-
-
-
6
-
-
-
-
-
-
-
-
12
6
6
-
-
-
-
-
-
-
-
-
-
-
-
-
673147
Kojima
-
Cloning of chicken lanosterol ...
Gallus gallus
Comp. Biochem. Physiol. A
145A
383-389
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
26
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674700
Lepesheva
CYP51 from Trypanosoma cruzi: ...
Trypanosoma cruzi
J. Biol. Chem.
281
3577-3585
2006
-
1
1
-
1
-
3
-
1
1
-
5
-
8
-
-
1
1
-
-
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
3
-
-
1
1
-
5
-
-
-
1
-
-
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677216
Troesken
Comparison of lanosterol-14 al ...
Candida albicans, Homo sapiens
Toxicology
228
24-32
2006
-
-
1
-
-
-
44
2
-
1
-
3
-
6
-
-
-
-
-
-
2
-
3
-
2
-
-
-
2
-
-
-
-
-
42
-
-
1
-
-
-
-
42
44
-
2
-
1
-
3
-
-
-
-
-
-
2
-
3
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
658808
Wyand
Sequence variation in the CYP5 ...
Blumeria graminis
Fungal Genet. Biol.
42
726-735
2005
-
-
1
-
1
-
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659097
Kudo
Effects of Y132H and F145L sub ...
Candida albicans
J. Biochem.
137
625-632
2005
-
1
-
-
2
-
4
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659513
Matsuura
Structural diversities of acti ...
Homo sapiens, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Biol. Chem.
280
9088-9096
2005
-
-
-
-
-
-
8
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671363
Mellado
Targeted gene disruption of th ...
Aspergillus fumigatus
Antimicrob. Agents Chemother.
49
2536-2538
2005
-
-
1
-
1
-
7
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671727
Waterman
Sterol 14alpha-demethylase, an ...
Acanthamoeba polyphaga, Homo sapiens, Methylococcus capsulatus, Mycobacterium tuberculosis, Trypanosoma brucei
Biochem. Biophys. Res. Commun.
338
418-422
2005
1
-
2
1
-
-
-
-
5
-
-
11
-
10
-
-
-
-
-
6
-
-
12
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
1
1
-
-
-
-
-
-
5
-
-
11
-
-
-
-
-
6
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672337
Ott
Flux of sterol intermediates i ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae FY1679
Biochim. Biophys. Acta
1735
111-118
2005
-
-
1
-
1
-
-
-
3
-
-
2
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673347
Fink
Cholesterogenic lanosterol 14a ...
Homo sapiens
Endocrinology
146
5321-5331
2005
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675865
Hankins
Upregulation of sterol C14-dem ...
Trypanosoma cruzi
Mol. Biochem. Parasitol.
144
68-75
2005
1
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676589
O'Brien
Lipid signaling in plants. Clo ...
Solanum chacoense
Plant Physiol.
139
734-749
2005
-
-
1
-
-
-
-
-
1
-
1
2
-
6
-
-
-
-
-
4
-
-
3
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
4
-
-
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
658561
Cotman
A functional cytochrome P450 l ...
Bos taurus, Mus musculus, Ovis aries
Endocrinology
145
1419-1426
2004
-
-
-
-
-
-
-
-
6
-
3
-
-
4
-
3
-
-
-
3
-
-
3
3
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
-
3
-
-
-
3
-
-
3
-
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659531
Sheng
Homology modeling of lanostero ...
Aspergillus fumigatus, Candida albicans
J. Biomol. Struct. Dyn.
22
91-99
2004
-
-
-
2
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675115
Giner
Sterol composition of Pneumocy ...
Pneumocystis jirovecii
J. Eukaryot. Microbiol.
51
634-643
2004
-
-
-
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657522
Morales
Characterization of a lanoster ...
Pneumocystis carinii
Am. J. Respir. Cell Mol. Biol.
29
232-238
2003
-
-
1
-
2
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659601
Burger
Virus-induced silencing of ste ...
Nicotiana benthamiana
J. Exp. Bot.
54
1675-1683
2003
-
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659901
Buckner
Cloning and analysis of Trypan ...
Trypanosoma cruzi
Mol. Biochem. Parasitol.
132
75-81
2003
-
-
1
-
1
-
-
-
-
-
1
-
-
5
-
-
-
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