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Literature summary for 1.14.14.154 extracted from

  • Cools, H.J.; Fraaije, B.A.; Kim, S.H.; Lucas, J.A.
    Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops (2006), Biochem. Soc. Trans., 34, 1219-1222.
    View publication on PubMed
Search for more literature for 1.14.14.154

Application

Application Comment Organism
agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Oculimacula yallundae
agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Blumeria graminis
agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Oculimacula acuformis
agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Zymoseptoria tritici
medicine the enzyme is a target for antifungal inhibitors Candida albicans

Protein Variants

Protein Variants Comment Organism
F180L the naturally occuring mutation is responsible for the resistance to triazoles Oculimacula acuformis
I381V the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole Zymoseptoria tritici
additional information the enzyme shows a number of polymorphisms at the amino acid level Oculimacula yallundae
additional information the enzyme shows a number of polymorphisms at the amino acid level Oculimacula acuformis
Y136F a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole Blumeria graminis
Y136F/K147Q a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole Blumeria graminis
Y137F the naturally occuring mutation does not affect triazole sensitivity Zymoseptoria tritici

Inhibitors

Inhibitors Comment Organism Structure
azole the organism shows reduced azole-sensitivity Zymoseptoria tritici
epoxiconazole
-
 Zymoseptoria tritici
imidazoles
-
 Oculimacula acuformis
imidazoles
-
 Oculimacula yallundae
additional information the enzyme is highly resistant to triadimenol Blumeria graminis
additional information Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles Oculimacula acuformis
Prochloraz
-
 Oculimacula yallundae
prothioconazole
-
 Zymoseptoria tritici
tebuconazole
-
 Zymoseptoria tritici
triazole
-
 Blumeria graminis
triazole sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview Candida albicans
triazoles
-
 Oculimacula yallundae
triazoles
-
 Zymoseptoria tritici

Organism

Organism UniProt Comment Textmining
Blumeria graminis
-
 f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51
-
Candida albicans
-
-
-
Oculimacula acuformis
-
 syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51
-
Oculimacula yallundae
-
 syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51
-
Zymoseptoria tritici
-
 septoria leaf blotch fungus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information residues Ile381 and Leu321 are involved in substrate recognition Zymoseptoria tritici ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP51
-
 Candida albicans
CYP51
-
 Oculimacula yallundae
CYP51
-
 Blumeria graminis
CYP51
-
 Oculimacula acuformis
CYP51
-
 Zymoseptoria tritici
cytochrome P450 sterol 14alpha-demethylase
-
 Candida albicans