Any feedback?
Literature summary for 1.14.14.154 extracted from
- Sterol 14alpha-demethylase cytochrome P 450 (CYP51), a P450 in all biological kingdoms (2007), Biochim. Biophys. Acta, 1770, 467-477.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| sequence comparison, phylogenetic analysis, heterologous overexpression | Homo sapiens |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Rattus norvegicus |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Saccharomyces cerevisiae |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Mycolicibacterium smegmatis |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Trypanosoma brucei |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Mycobacterium tuberculosis |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Trypanosoma cruzi |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Candida albicans |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Sorghum bicolor |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Methylococcus capsulatus |
| sequence comparison, phylogenetic analysis, heterologous overexpression | Ustilago maydis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 14alpha-amino-lanosterol | - |
Candida albicans |  |
| 14alpha-amino-lanosterol | - |
Trypanosoma cruzi | |
| 15-hydroxy-lanosterol | - |
Homo sapiens | |
| 15-keto-lanosterol | - |
Homo sapiens | |
| 26-oxo-lanosterol | - |
Homo sapiens | |
| 7-oxo-lanosterol | - |
Homo sapiens | |
| imidazole inhibitors | - |
Candida albicans | |
| imidazole inhibitors | - |
Homo sapiens | |
| imidazole inhibitors | - |
Methylococcus capsulatus | |
| imidazole inhibitors | - |
Mycobacterium tuberculosis | |
| imidazole inhibitors | - |
Mycolicibacterium smegmatis | |
| imidazole inhibitors | - |
Rattus norvegicus | |
| imidazole inhibitors | - |
Saccharomyces cerevisiae | |
| imidazole inhibitors | - |
Sorghum bicolor | |
| imidazole inhibitors | - |
Trypanosoma brucei | |
| imidazole inhibitors | - |
Trypanosoma cruzi | |
| imidazole inhibitors | - |
Ustilago maydis | |
| additional information | 14alpha-carboaldehyde reaction intermediates are effective in competitive enzyme inhibition and as hypocholesterolemic agents | Homo sapiens | |
| triazole inhibitors | - |
Candida albicans | |
| triazole inhibitors | - |
Homo sapiens | |
| triazole inhibitors | - |
Methylococcus capsulatus | |
| triazole inhibitors | - |
Mycobacterium tuberculosis | |
| triazole inhibitors | - |
Mycolicibacterium smegmatis | |
| triazole inhibitors | - |
Rattus norvegicus | |
| triazole inhibitors | - |
Saccharomyces cerevisiae | |
| triazole inhibitors | - |
Sorghum bicolor | |
| triazole inhibitors | - |
Trypanosoma brucei | |
| triazole inhibitors | - |
Trypanosoma cruzi | |
| triazole inhibitors | - |
Ustilago maydis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Saccharomyces cerevisiae | - |
- |
| microsome | - |
Trypanosoma brucei | - |
- |
| microsome | - |
Trypanosoma cruzi | - |
- |
| microsome | - |
Candida albicans | - |
- |
| microsome | - |
Sorghum bicolor | - |
- |
| microsome | - |
Ustilago maydis | - |
- |
| soluble | - |
Mycolicibacterium smegmatis | - |
- |
| soluble | - |
Mycobacterium tuberculosis | - |
- |
| soluble | - |
Methylococcus capsulatus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Saccharomyces cerevisiae | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Candida albicans | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Trypanosoma cruzi | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Ustilago maydis | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Saccharomyces cerevisiae | - |
? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycolicibacterium smegmatis | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Candida albicans | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Methylococcus capsulatus | the enzyme is involved in ergosterol and cholesterol biosynthesis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Trypanosoma brucei | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Trypanosoma cruzi | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | ? | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | Trypanosoma brucei | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | Trypanosoma cruzi | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | Sorghum bicolor | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Methylococcus capsulatus | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Mycolicibacterium smegmatis | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sorghum bicolor | - |
- |
- |
| Trypanosoma brucei | - |
- |
- |
| Trypanosoma cruzi | - |
- |
- |
| Ustilago maydis | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
substrate specificity | Homo sapiens |
| additional information | - |
substrate specificity | Rattus norvegicus |
| additional information | - |
substrate specificity | Saccharomyces cerevisiae |
| additional information | - |
substrate specificity | Mycolicibacterium smegmatis |
| additional information | - |
substrate specificity | Trypanosoma brucei |
| additional information | - |
substrate specificity | Mycobacterium tuberculosis |
| additional information | - |
substrate specificity | Trypanosoma cruzi |
| additional information | - |
substrate specificity | Candida albicans |
| additional information | - |
substrate specificity | Sorghum bicolor |
| additional information | - |
substrate specificity | Methylococcus capsulatus |
| additional information | - |
substrate specificity | Ustilago maydis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycobacterium tuberculosis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Homo sapiens | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Rattus norvegicus | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Saccharomyces cerevisiae | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Mycobacterium tuberculosis | ? | - |
? | |
| 24,25-dihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Candida albicans | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycobacterium tuberculosis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Ustilago maydis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Mycobacterium tuberculosis | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Trypanosoma cruzi | ? | - |
? | |
| 24-methylenedihydrolanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Ustilago maydis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Saccharomyces cerevisiae | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycolicibacterium smegmatis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycobacterium tuberculosis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Methylococcus capsulatus | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Homo sapiens | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Rattus norvegicus | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Mycolicibacterium smegmatis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Mycobacterium tuberculosis | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Candida albicans | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in ergosterol and cholesterol biosynthesis | Methylococcus capsulatus | ? | - |
? | |
| additional information | poor activity with lanosterol, 24,25-dihydrolanosterol, and 24-methylenedihydrolanosterol, the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Trypanosoma brucei | ? | - |
? | |
| additional information | poor activity with lanosterol, 24,25-dihydrolanosterol, and 24-methylenedihydrolanosterol, the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Sorghum bicolor | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Homo sapiens | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Rattus norvegicus | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Mycolicibacterium smegmatis | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Trypanosoma cruzi | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Candida albicans | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Methylococcus capsulatus | ? | - |
? | |
| additional information | the regio- and stereospecific 14alpha-demethylation CYP51 reaction proceeds in three steps, each requiring one molecule of oxygen and two NADPH-derived reducing equivalents, via 14alpha-carboxyalcohol and 14alpha-carboxyaldehyde intermediates, cleavage of the the C-C bond by radical or Bayer-Villiger mechanism, DELTA14,15 double bond introduction into the sterol core | Ustilago maydis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma brucei | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycobacterium tuberculosis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sorghum bicolor | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | low activity | Trypanosoma cruzi | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Trypanosoma brucei | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Mycobacterium tuberculosis | ? | - |
? | |
| norlanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Trypanosoma cruzi | ? | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma brucei | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sorghum bicolor | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | low activity | Trypanosoma cruzi | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | preferred substrate | Mycobacterium tuberculosis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | preferred substrate | Candida albicans | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Trypanosoma brucei | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Mycobacterium tuberculosis | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Trypanosoma cruzi | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in functional sterol, ergosterol, and sitosterol biosynthesis | Sorghum bicolor | 4alpha-methyl-5alpha-ergost-8,14,24(28)-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | comparison of CYP51 family enzyme structures, overview | Homo sapiens |
| More | comparison of CYP51 family enzyme structures, overview | Rattus norvegicus |
| More | comparison of CYP51 family enzyme structures, overview | Saccharomyces cerevisiae |
| More | comparison of CYP51 family enzyme structures, overview | Mycolicibacterium smegmatis |
| More | comparison of CYP51 family enzyme structures, overview | Trypanosoma brucei |
| More | comparison of CYP51 family enzyme structures, overview | Mycobacterium tuberculosis |
| More | comparison of CYP51 family enzyme structures, overview | Trypanosoma cruzi |
| More | comparison of CYP51 family enzyme structures, overview | Candida albicans |
| More | comparison of CYP51 family enzyme structures, overview | Sorghum bicolor |
| More | comparison of CYP51 family enzyme structures, overview | Methylococcus capsulatus |
| More | comparison of CYP51 family enzyme structures, overview | Ustilago maydis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP51 | - |
Homo sapiens |
| CYP51 | - |
Rattus norvegicus |
| CYP51 | - |
Saccharomyces cerevisiae |
| CYP51 | - |
Mycolicibacterium smegmatis |
| CYP51 | - |
Trypanosoma brucei |
| CYP51 | - |
Mycobacterium tuberculosis |
| CYP51 | - |
Trypanosoma cruzi |
| CYP51 | - |
Candida albicans |
| CYP51 | - |
Sorghum bicolor |
| CYP51 | - |
Methylococcus capsulatus |
| CYP51 | - |
Ustilago maydis |
| More | the enzyme belongs to the CYP51 family | Homo sapiens |
| More | the enzyme belongs to the CYP51 family | Rattus norvegicus |
| More | the enzyme belongs to the CYP51 family | Saccharomyces cerevisiae |
| More | the enzyme belongs to the CYP51 family | Mycolicibacterium smegmatis |
| More | the enzyme belongs to the CYP51 family | Trypanosoma brucei |
| More | the enzyme belongs to the CYP51 family | Mycobacterium tuberculosis |
| More | the enzyme belongs to the CYP51 family | Trypanosoma cruzi |
| More | the enzyme belongs to the CYP51 family | Candida albicans |
| More | the enzyme belongs to the CYP51 family | Sorghum bicolor |
| More | the enzyme belongs to the CYP51 family | Methylococcus capsulatus |
| More | the enzyme belongs to the CYP51 family | Ustilago maydis |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Homo sapiens |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Rattus norvegicus |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Saccharomyces cerevisiae |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Mycolicibacterium smegmatis |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Trypanosoma brucei |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Mycobacterium tuberculosis |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Trypanosoma cruzi |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Candida albicans |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Sorghum bicolor |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Methylococcus capsulatus |
| sterol 14alpha-demethylase cytochrome P 450 | - |
Ustilago maydis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Ferredoxin | a ferredoxin-bound enzyme | Methylococcus capsulatus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
