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Literature summary for 1.14.14.154 extracted from
- Cholesterogenic lanosterol 14alpha-demethylase (CYP51) is an immediate early response gene (2005), Endocrinology, 146, 5321-5331.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme mRNA is increased by forskolin, cAMP-dependent transactivation of CYP51 | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene CYP51, the proximal promoter of CYP51 contains a conserved region with clustered regulatory elements: GC box, CRE-like cAMP-response elements, and sterol regulatory element, i.e. SRE, overview, in lipid-rich, and SREBP-poor conditions, the CYP51 mRNA amount drops gradually, the promoter activity is diminished, expression in JEG-3 choriocarcinoma cells and in Hep-G2 hepatocarcinoma cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | the enzyme is regulated by cholesterol feedback regulation through sterol regulatory element binding proteins, i.e. SREBPs, regulation mechanisms of enzyme expression, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gene CYP51 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is regulated by cholesterol feedback regulation through sterol regulatory element binding proteins, i.e. SREBPs, regulation mechanisms of enzyme expression, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP51 | - |
Homo sapiens |
| lanosterol 14alpha-demethylase | - |
Homo sapiens |
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