Cloned (Comment) | Organism |
---|---|
gene CYP51, DNA and amino acid sequence determination and analysis, functional expression as GST-tagged enzyme in Escherichia coli | Taiwanofungus camphoratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
itraconazole | a fungicide that targets CYP51 and as an inhibitor causes the accumulation of lanosterol and reduced ergosterol biosynthesis in fungi, also induces AcCYP51 expression after 24 h of treatment | Taiwanofungus camphoratus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61900 | - |
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation | Taiwanofungus camphoratus |
84600 | - |
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation | Taiwanofungus camphoratus |
87900 | - |
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation | Taiwanofungus camphoratus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taiwanofungus camphoratus | A8DBU6 | i.e. Antrodia camphorata, gene CYP51 | - |
Taiwanofungus camphoratus TFRIB 470 | A8DBU6 | i.e. Antrodia camphorata, gene CYP51 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | expression analysis at different developmental and growth stages, overview | Taiwanofungus camphoratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Taiwanofungus camphoratus | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Taiwanofungus camphoratus TFRIB 470 | 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation | Taiwanofungus camphoratus |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Taiwanofungus camphoratus |
lanosterol 14alpha-demethylase | - |
Taiwanofungus camphoratus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Taiwanofungus camphoratus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Taiwanofungus camphoratus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Taiwanofungus camphoratus | sequence calculation | - |
6.12 |
Organism | Comment | Expression |
---|---|---|
Taiwanofungus camphoratus | transcription of AcCYP51 increases in various culture conditions including adding squalene, lanosterol, itroconazole, and oleic acid as inducers. Itroconazol, a fungicide that targets CYP51 and as an inhibitor causes the accumulation of lanosterol and reduced ergosterol biosynthesis in fungi, also induces AcCYP51 expression after 24 h of treatment | up |
General Information | Comment | Organism |
---|---|---|
metabolism | sterol 14alpha-demethylase is one of the key enzymes for sterol biosynthesis in fungi | Taiwanofungus camphoratus |