Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.154 extracted from

  • Lee, C.H.; Hsu, K.H.; Wang, S.Y.; Chang, T.T.; Chu, F.H.; Shaw, J.F.
    Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea (2010), J. Agric. Food Chem., 58, 4800-4807.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP51, DNA and amino acid sequence determination and analysis, functional expression as GST-tagged enzyme in Escherichia coli Taiwanofungus camphoratus

Inhibitors

Inhibitors Comment Organism Structure
itraconazole a fungicide that targets CYP51 and as an inhibitor causes the accumulation of lanosterol and reduced ergosterol biosynthesis in fungi, also induces AcCYP51 expression after 24 h of treatment Taiwanofungus camphoratus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61900
-
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation Taiwanofungus camphoratus
84600
-
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation Taiwanofungus camphoratus
87900
-
x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation Taiwanofungus camphoratus

Organism

Organism UniProt Comment Textmining
Taiwanofungus camphoratus A8DBU6 i.e. Antrodia camphorata, gene CYP51
-
Taiwanofungus camphoratus TFRIB 470 A8DBU6 i.e. Antrodia camphorata, gene CYP51
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression analysis at different developmental and growth stages, overview Taiwanofungus camphoratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Taiwanofungus camphoratus 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Taiwanofungus camphoratus TFRIB 470 4,4-dimethylcholesta-8,14,24-trienol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Subunits

Subunits Comment Organism
? x * 87900, full-length recombinant GST-tagged enzyme, SDS-PAGE, x * 84600, mature recombinant GST-tagged enzyme, SDS-PAGE, x * 61900, about, sequence calculation Taiwanofungus camphoratus

Synonyms

Synonyms Comment Organism
CYP51
-
Taiwanofungus camphoratus
lanosterol 14alpha-demethylase
-
Taiwanofungus camphoratus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Taiwanofungus camphoratus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Taiwanofungus camphoratus

pI Value

Organism Comment pI Value Maximum pI Value
Taiwanofungus camphoratus sequence calculation
-
6.12

Expression

Organism Comment Expression
Taiwanofungus camphoratus transcription of AcCYP51 increases in various culture conditions including adding squalene, lanosterol, itroconazole, and oleic acid as inducers. Itroconazol, a fungicide that targets CYP51 and as an inhibitor causes the accumulation of lanosterol and reduced ergosterol biosynthesis in fungi, also induces AcCYP51 expression after 24 h of treatment up

General Information

General Information Comment Organism
metabolism sterol 14alpha-demethylase is one of the key enzymes for sterol biosynthesis in fungi Taiwanofungus camphoratus