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Literature summary for 1.14.14.154 extracted from

  • Yan, X.; Ma, W.; Li, Y.; Wang, H.; Que, Y.; Ma, Z.; Talbot, N.; Wang, Z.
    A sterol 14alph-demethylase is required for conidiation, virulence and for mediating sensitivity to sterol demethylation inhibitors by the rice blast fungus Magnaporthe oryzae (2011), Fungal Genet. Biol., 48, 144-153.
    View publication on PubMed
Search for more literature for 1.14.14.154

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoform Cyp51A Pyricularia oryzae 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Pyricularia oryzae
-
 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Pyricularia oryzae Guy11
-
 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Pyricularia oryzae
-
-
-
Pyricularia oryzae Guy11
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
conidium
-
 Pyricularia oryzae
-
hypha
-
 Pyricularia oryzae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Pyricularia oryzae 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Pyricularia oryzae Guy11 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
Cyp51A isoform Pyricularia oryzae
CYP51B isoform Pyricularia oryzae
lanosterol 14alpha-demethylase
-
 Pyricularia oryzae

Expression

Organism Comment Expression
Pyricularia oryzae expression of both isoform CYP51A and CYP51B is significantly induced by exposure to sterol demethylation inhibitor fungicides tebuconazole, propiconazole, and prochloraz up

General Information

General Information Comment Organism
malfunction deletion mutants of CYP51A are morphologically indistinguishable from the isogenic wild type strain in vegetative culture, but are impaired in both conidiation and virulence. The deletion of isoform CYP51B does not result in any obvious phenotypic changes. The deletion mutant DELTAcyp51A is also highly sensitive to sterol demethylation inhibitor fungicides, while DELTAcyp51B mutants are unchanged in their sensitivity to these fungicides. Pyricularia oryzae
physiological function isoform CYP51A is required for conidiation, virulence and for mediating sensitivity to sterol demethylation inhibitors by Magnaporthe oryzae. Isoform CYP51A is expressed at low levels during vegetative growth, conidiation and appressorium formation Pyricularia oryzae