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Literature summary for 1.14.14.154 extracted from

  • Emami, S.; Banipoulad, T.; Irannejad, H.; Foroumadi, A.; Falahati, M.; Ashrafi-Khozani, M.; Sharifynia, S.
    Imidazolylchromanones containing alkyl side chain as lanosterol 14alpha-demethylase inhibitors: synthesis, antifungal activity and docking study (2014), J. Enzyme Inhib. Med. Chem., 29, 263-271.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with fluconazole Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
(Z)-2,3-dihydro-3-(1H-imidazol-1-yl)-2-(1-butyl)-4H-1-benzopyran-4-one oxime
-
Mycobacterium tuberculosis
(Z)-trans-2,3-dihydro-3-(1H-imidazol-1-yl)-2-(1-pentyl)-4H-1-benzopyran-4-one oxime
-
Mycobacterium tuberculosis
fluconazole
-
Mycobacterium tuberculosis
miconazole
-
Mycobacterium tuberculosis
trans-2,3-dihydro-3-(1H-imidazol-1-yl)-2-(1-heptyl)-4H-1-benzopyran-4-one nitrate
-
Mycobacterium tuberculosis
trans-2,3-dihydro-3-(1H-imidazol-1-yl)-2-(1-hexyl)-4H-1-benzopyran-4-one nitrate
-
Mycobacterium tuberculosis
trans-2,3-dihydro-3-(1H-imidazol-1-yl)-2-(1-pentyl)-4H-1-benzopyran-4-one nitrate
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Mycobacterium tuberculosis
-
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Mycobacterium tuberculosis H37Rv
-
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPP9
-
-
Mycobacterium tuberculosis H37Rv P9WPP9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Mycobacterium tuberculosis 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Mycobacterium tuberculosis H37Rv 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP51
-
Mycobacterium tuberculosis
lanosterol 14alpha-demethylase
-
Mycobacterium tuberculosis