Application | Comment | Organism |
---|---|---|
medicine | Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, which depends on the production of endogenous sterols, and therefore can be blocked by sterol 14alpha-demethylase inhibitors | Trypanosoma cruzi |
pharmacology | Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, which depends on the production of endogenous sterols, and therefore can be blocked by sterol 14alpha-demethylase inhibitors | Trypanosoma cruzi |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli strain HMS174(DE3) | Trypanosoma cruzi |
Crystallization (Comment) | Organism |
---|---|
for crystallization purposes, an N-terminal truncated construct is used where the membrane anchor sequence is replaced with the 5-amino acid sequence fragment MAKKT-. Crystals are grown at 23°C using the hanging-drop vapor diffusion method | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)-benzamide | - |
Trypanosoma cruzi | |
(R)-N-(2-(1H-imidazol-1-yl)-1-phenylethyl)-4'-chlorobiphenyl-4-carboxamide | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q7Z1V1 | - |
- |
Trypanosoma cruzi CL Brener | Q7Z1V1 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
eburicol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | ? | - |
? | |
eburicol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi CL Brener | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Trypanosoma cruzi |