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Literature summary for 1.14.14.154 extracted from

  • Warrilow, A.G.; Price, C.L.; Parker, J.E.; Rolley, N.J.; Smyrniotis, C.J.; Hughes, D.D.; Thoss, V.; Nes, W.D.; Kelly, D.E.; Holman, T.R.; Kelly, S.L.
    Azole antifungal sensitivity of sterol 14alpha-demethylase (CYP51) and CYP5218 from Malassezia globosa (2016), Sci. Rep., 6, 27690 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Malassezia globosa

Inhibitors

Inhibitors Comment Organism Structure
fluconazole
-
Malassezia globosa
itraconazole
-
Malassezia globosa
ketaminazole
-
Malassezia globosa
ketoconazole
-
Malassezia globosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0421
-
obtusifoliol 37°C, pH 7.2 Malassezia globosa
0.0551
-
lanosterol 37°C, pH 7.2 Malassezia globosa
0.0559
-
eburicol 37°C, pH 7.2 Malassezia globosa

Organism

Organism UniProt Comment Textmining
Malassezia globosa A8Q3I7
-
-
Malassezia globosa CBS 7966 A8Q3I7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Malassezia globosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa ?
-
?
eburicol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa CBS 7966 ?
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa ?
-
?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa CBS 7966 ?
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa ?
-
?
obtusifoliol + [reduced NADPH-hemoprotein reductase] + O2
-
Malassezia globosa CBS 7966 ?
-
?

Synonyms

Synonyms Comment Organism
CYP51
-
Malassezia globosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Malassezia globosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.03
-
lanosterol 37°C, PH 7.2 Malassezia globosa
0.06
-
obtusifoliol 37°C, PH 7.2 Malassezia globosa
0.09
-
eburicol 37°C, PH 7.2 Malassezia globosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Malassezia globosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.176
-
37°C, pH 7.2 Malassezia globosa ketoconazole
0.188
-
37°C, pH 7.2 Malassezia globosa itraconazole
0.206
-
37°C, pH 7.2 Malassezia globosa fluconazole
0.321
-
37°C, pH 7.2 Malassezia globosa ketaminazole

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.54
-
lanosterol 37°C, pH 7.2 Malassezia globosa
1.4
-
obtusifoliol 37°C, pH 7.2 Malassezia globosa
1.6
-
eburicol 37°C, pH 7.2 Malassezia globosa