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Literature summary for 1.14.14.17 extracted from

  • Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.
    Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues (1977), Biochim. Biophys. Acta, 487, 204-211.
    View publication on PubMed
Search for more literature for 1.14.14.17

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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 Rattus norvegicus
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
squalene + electron donor + O2 Rattus norvegicus may be rate-limiting step in cholesterol biosynthesis in non-cholesterogenic tissues (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
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additional information very low activity in non-cholesterogenic tissues: brain, muscle, lung, placenta, kidney Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + electron donor + O2 may be rate-limiting step in cholesterol biosynthesis in non-cholesterogenic tissues Rattus norvegicus (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
-
 ?
squalene + NAD(P)H + O2
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 Rattus norvegicus (S)-squalene-2,3-epoxide + NADP+ + H2O
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 ?