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Literature summary for 1.14.14.17 extracted from

  • Ryder, N.S.; Dupont, M.C.
    Properties of a particulate squalene epoxidase from Candida albicans (1984), Biochim. Biophys. Acta, 794, 466-471.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-heptyl-4-hydroxyquinoline N-oxide 0.1 mM, 236% stimulation Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxymercuribenzoate 1 mM, 35% inhibition Candida albicans
antimycin A 0.1 mM, 44% inhibition Candida albicans
bovine serum albumin
-
Candida albicans
chloromercuriphenylsulfonate 1 mM, 35% inhibition Candida albicans
Cu2+ 5 mM, 99% inhibition Candida albicans
deoxycholate
-
Candida albicans
N-ethylmaleimide 1 mM, 35% inhibition Candida albicans
rotenone 0.1 mM, 67% inhibition Candida albicans
Triton X-100
-
Candida albicans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
squalene
-
Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Candida albicans
-
-

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Storage Stability

Storage Stability Organism
-20°C, 5 d, 75% loss of activity Candida albicans
stable for several months in liquid nitrogen Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + NAD(P)H + O2
-
Candida albicans (S)-squalene-2,3-epoxide + NADP+ + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
FAD required for activity Candida albicans
additional information FMN cannot replace FAD as cofactor Candida albicans