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Literature summary for 1.14.14.17 extracted from

  • Pasrija, R.; Krishnamurthy, S.; Prasad, T.; Ernst, J.F.; Prasad, R.
    Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans (2005), J. Antimicrob. Chemother., 55, 905-913.
    View publication on PubMed
Search for more literature for 1.14.14.17

Cloned(Commentary)

Cloned (Comment) Organism
gene ERG1, subcloning in Escherichi acoli strain DH5alpha Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information construction of a disruption mutant of both gene ERG1 alleles, which is lethal, and of a heterozygous ERG1 disruptant mutant by disruption of one ERG1 allele, while the second is controlled by the regulable promotor MET3p repressable by methionine and cysteine, the heterozyygous mutant strain does not produce ergosterol, conditional mutant shows reduced passive diffusion of drug into the cells, hyphal morphogenesis is affected in the mutant, overview Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme provides resistance to the drugs fluconazole, cycloheximide, ketoconazole, amphotericin B, nystatin, and terbafine, the repressable heterozygous ERG1 mutant strain is hypersensitive to the drugs under repressing conditions and increased sensitive, compared to the wild-type, under non-repressing conditions Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55300
-
 x * 55300, Erg1 protein, SDS-PAGE Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Candida albicans the enzyme affects morphogenesis and drug susceptibilities ?
-
 ?
squalene + reduced acceptor + O2 Candida albicans epoxidation of squalene is the first step in cholesterol biosynthesis (S)-squalene-2,3-epoxide + acceptor + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
 gene ERG1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme affects morphogenesis and drug susceptibilities Candida albicans ?
-
 ?
squalene + reduced acceptor + O2
-
 Candida albicans (S)-squalene-2,3-epoxide + acceptor + H2O
-
 ?
squalene + reduced acceptor + O2 epoxidation of squalene is the first step in cholesterol biosynthesis Candida albicans (S)-squalene-2,3-epoxide + acceptor + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 55300, Erg1 protein, SDS-PAGE Candida albicans

Synonyms

Synonyms Comment Organism
squalene epoxidase
-
 Candida albicans