BRENDA - Enzyme Database show
show all sequences of 1.14.14.17

Arabidopsis squalene epoxidase 3 (SQE3) complements SQE1 and is important for embryo development and bulk squalene epoxidase activity

Laranjeira, S.; Amorim-Silva, V.; Esteban, A.; Arro, M.; Ferrer, A.; Tavares, R.M.; Botella, M.A.; Rosado, A.; Azevedo, H.; Mol. Plant 8, 1090-1102 (2015)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
terbinafine
-
Arabidopsis thaliana
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Arabidopsis thaliana
5783
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
squalene + [reduced NADPH-hemoprotein reductase] + O2
Arabidopsis thaliana
-
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Arabidopsis thaliana
-
root
-
Arabidopsis thaliana
-
shoot
-
Arabidopsis thaliana
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
squalene + [reduced NADPH-hemoprotein reductase] + O2
-
734739
Arabidopsis thaliana
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0009
-
pH and temperature not specified in the publication
Arabidopsis thaliana
terbinafine
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0009
-
pH and temperature not specified in the publication
Arabidopsis thaliana
terbinafine
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
terbinafine
-
Arabidopsis thaliana
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Arabidopsis thaliana
5783
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
squalene + [reduced NADPH-hemoprotein reductase] + O2
Arabidopsis thaliana
-
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Arabidopsis thaliana
-
root
-
Arabidopsis thaliana
-
shoot
-
Arabidopsis thaliana
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
squalene + [reduced NADPH-hemoprotein reductase] + O2
-
734739
Arabidopsis thaliana
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
metabolism
the isoform SQE3 is able to complement isoform SQE1 function
Arabidopsis thaliana
physiological function
the enzyme is important for embryo development and bulk squalene epoxidase activity
Arabidopsis thaliana
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the isoform SQE3 is able to complement isoform SQE1 function
Arabidopsis thaliana
physiological function
the enzyme is important for embryo development and bulk squalene epoxidase activity
Arabidopsis thaliana
Other publictions for EC 1.14.14.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745145
Zhang
Overexpression of the squalen ...
Ganoderma lucidum
J. Agric. Food Chem.
65
4683-4690
2017
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745376
Chua
A conserved degron containing ...
Homo sapiens
J. Biol. Chem.
292
19959-19973
2017
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1
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746469
Ha
Squalene epoxidase plays a cr ...
Sus scrofa
Sci. Rep.
7
16740
2017
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1
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1
1
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745963
Ma
-
Cloning and characterization ...
Panax vietnamensis var. fuscidiscus
Pak. J. Bot.
48
2453-2465
2016
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2
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746125
Guo
Molecular characterization, e ...
Gynostemma pentaphyllum
Plant Physiol. Biochem.
109
230-239
2016
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1
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3
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1
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1
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1
1
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1
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746410
Zhang
Molecular cloning and promote ...
Betula platyphylla
Protoplasma
253
1347-1363
2016
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5
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1
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746443
Brown
Squalene epoxidase is a bona ...
Homo sapiens
Sci. Rep.
6
19435
2016
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734315
Howe
The regulatory domain of squal ...
Homo sapiens
J. Biol. Chem.
290
27533-27544
2015
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2
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734595
Drozdikova
Production of squalene by lact ...
Kluyveromyces lactis
Lett. Appl. Microbiol.
61
77-84
2015
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734739
Laranjeira
Arabidopsis squalene epoxidase ...
Arabidopsis thaliana
Mol. Plant
8
1090-1102
2015
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1
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1
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4
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4
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2
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735329
Sui
Squalene epoxidase (SQLE) prom ...
Homo sapiens
Tumour Biol.
36
6173-6179
2015
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746180
Uchida
Isolation and characterizatio ...
Botryococcus braunii
PLoS ONE
10
e0122649
2015
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5
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1
2
2
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727560
Garaiova
Squalene epoxidase as a target ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
FEMS Yeast Res.
14
310-323
2014
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1
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1
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55
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733299
Stevenson
Squalene mono-oxygenase, a key ...
Homo sapiens
Biochem. J.
461
435-442
2014
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1
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1
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744535
Zare
-
Antifungal activity of biogen ...
Candida albicans, Candida albicans ATCC14053
Biotechnol. Appl. Biochem.
61
395-400
2014
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746530
Zhang
Expression and significance o ...
Homo sapiens
Thorac. Cancer
5
275-280
2014
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715725
Nowosielski
Detailed mechanism of squalene ...
Saccharomyces cerevisiae
J. Chem. Inf. Model.
51
455-462
2011
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723497
Kim
Gene regulation patterns in tr ...
Bupleurum falcatum
Planta
233
343-355
2011
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696762
Gerpe
5-Nitrofuranes and 5-nitrothio ...
Trypanosoma cruzi
Bioorg. Med. Chem.
17
7500-7509
2009
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10
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697143
Seiki
Pharmacologic inhibition of sq ...
Canis lupus familiaris, Homo sapiens, Nicotiana sp.
Cardiol. Rev.
17
70-76
2009
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1
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3
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700657
Han
Regulation of ginsenoside and ...
Panax ginseng
Phytochemistry
00
0000
2009
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1
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700760
Pose
Identification of the Arabidop ...
Arabidopsis thaliana
Plant J.
59
63-76
2009
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1
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684491
Ruckenstuhl
Structure-function correlation ...
Saccharomyces cerevisiae
Antimicrob. Agents Chemother.
52
1496-1499
2008
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9
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3
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1
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9
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Squalene epoxidase, located on ...
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Characterization of squalene e ...
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Site-directed mutagenesis of c ...
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A squalene epoxidase is involv ...
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Expression of the gene for ste ...
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Novel 3-phenylprop-2-ynylamine ...
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Squalene epoxidase as hypochol ...
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Inhibition of squalene synthas ...
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Sawada
Effect of FR194738, a potent i ...
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438213
Laden
Inhibition of human squalene m ...
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438208
Laden
Cloning, heterologous expressi ...
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Abe
Inhibition of vertebrate squal ...
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Abe
Green tea polyphenols: novel a ...
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Abe
Galloyl esters from rhubarb ar ...
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Favre
Characterization of squalene e ...
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Purification and characterizat ...
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Enzymic properties of squalene ...
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438198
Jordan
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Squalene oxidase: the elusive ...
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M'Baya
In vitro assay of squalene epo ...
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438200
Ono
Squalene epoxidase from rat li ...
Rattus norvegicus
Methods Enzymol.
110
375-380
1985
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2
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438202
Ryder
Inhibition of squalene epoxida ...
Candida albicans, Candida parapsilosis, Rattus norvegicus
Biochem. J.
230
765-770
1985
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438203
Ryder
Properties of a particulate sq ...
Candida albicans
Biochim. Biophys. Acta
794
466-471
1984
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9
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2
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438199
Ono
Purification and partial chara ...
Rattus norvegicus
Biochim. Biophys. Acta
709
84-90
1982
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1
1
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438196
Ono
Purification of squalene epoxi ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
96
522-528
1980
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2
1
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1
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438204
Lin
Roles of phospholipid and dete ...
Rattus norvegicus
Biochemistry
19
5135-5140
1980
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438194
Ferguson
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
252
5381-5385
1977
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1
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438197
Astruc
Squalene epoxidase and oxidosq ...
Rattus norvegicus
Biochim. Biophys. Acta
487
204-211
1977
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438193
Van Tamelen
Enzymic epoxidation of squalen ...
Rattus norvegicus
J. Am. Chem. Soc.
97
1252-1253
1975
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5
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1
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5
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438195
Ono
Solubilization and partial cha ...
Rattus norvegicus
J. Biol. Chem.
250
1571-1579
1975
1
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438192
Tai
Squalene epoxidase of rat live ...
Rattus norvegicus
J. Biol. Chem.
247
3767-3773
1972
1
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