Literature summary for 1.14.14.18 extracted from

Lad, L.; Schuller, D.J.; Shimizu, H.; Friedman, J.; Li, H.; Ortiz de Montellano, P.R.; Poulos, T.L.
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1 (2003), J. Biol. Chem., 278, 7834-7843.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
apo-enzyme and in complex with heme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme HO-1	-

Reaction

Reaction	Comment	Organism	Reaction ID
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O	binding of heme stabilizes the solvent H-bonded network in the active site required for proper catalysis	Homo sapiens	a

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Release 2023.1 (January 2023)