Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.18 extracted from

  • Ogborne, R.M.; Rushworth, S.A.; OConnell, M.A.
    Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2 (2008), Biochem. Biophys. Res. Commun., 373, 584-588.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
additional information epigallocatechin activates heme oxygenase-1 expression via protein kinase Cdelta, not PKCalpha and PKCbeta, and Nrf2, siRNA knock down of Nrf2 significantly inhibits EGC-induced HO-1 expression, inhibition of PKCdelta, e.g. by Ro-31-8220, decreases EGC-induced HO-1 mRNA expression, whereas MAP kinase and phosphatidylinositol-3-kinase pathway inhibitors have no significant effect, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens heme oxygenase-1 is regulated by the Nrf2/anti-oxidant response element, ARE, pathway, which plays an important role in regulating cellular anti-oxidants biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-
THP-1 cell a monocytic leukaemia cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 heme oxygenase-1 is regulated by the Nrf2/anti-oxidant response element, ARE, pathway, which plays an important role in regulating cellular anti-oxidants Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Homo sapiens
HO-1
-
 Homo sapiens