Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.18 extracted from

  • Gruber, F.; Oskolkova, O.; Leitner, A.; Mildner, M.; Mlitz, V.; Lengauer, B.; Kadl, A.; Mrass, P.; Kroenke, G.; Binder, B.R.; Bochkov, V.N.; Leitinger, N.; Tschachler, E.
    Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells (2007), J. Biol. Chem., 282, 16934-16941.
    View publication on PubMed
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
additional information HO-1 is strongly induced in the skin after long wave ultraviolet radiation, UVA-1 irradiation generates oxidized phospholipids derived from 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine that mediate the expression of HO-1 in skin cells, epoxyisoprostanephosphatidylcholine also induces the enzyme in the skin, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens HO-1 is a key enzyme in the cellular response to tissue injury and oxidative stress. HO-1 enzymatic activity results in the formation of the cytoprotective metabolites CO and biliverdin biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
fibroblast dermal Homo sapiens
-
keratinocyte epidermal Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 HO-1 is a key enzyme in the cellular response to tissue injury and oxidative stress. HO-1 enzymatic activity results in the formation of the cytoprotective metabolites CO and biliverdin Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Homo sapiens
HO-1
-
 Homo sapiens