Literature summary for 1.14.14.18 extracted from

Hsieh, C.H.; Jeng, S.F.; Hsieh, M.W.; Chen, Y.C.; Rau, C.S.; Lu, T.H.; Chen, S.S.
Statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide (2008), Toxicol. Sci., 102, 150-159.

Search for more literature for 1.14.14.18

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	simvastatin induces the enzyme in neurons, HO-1 upregulation is significantly associated with increased nuclear factor kappa B activation, manifested as IkappaBalpha phosphorylation and p65 nuclear translocation, as well as increased production of superoxides, inhibition of the effects by zinc protoporphyrin	Mus musculus
additional information	simvastatin induces the enzyme in neurons, HO-1 upregulation is significantly associated with increased nuclear factor kappa B activation, manifested as IkappaBalpha phosphorylation and p65 nuclear translocation, as well as increased production of superoxides, inhibition of the effects by zinc protoporphyrin	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis	Mus musculus
expression analysis	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	RNA interference with HO-1 siRNA reduces the expression of HO-1 transcripts and protein as well as oxygen radical production	Mus musculus
additional information	RNA interference with HO-1 siRNA reduces the expression of HO-1 transcripts and protein as well as oxygen radical production	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
zinc protoporphyrin	-	Mus musculus
zinc protoporphyrin	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
heme + AH2 + O2	Mus musculus	statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide, overview	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	Rattus norvegicus	statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide, overview	biliverdin + Fe2+ + CO + A + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P14901	-	-
Rattus norvegicus	P06762	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C6 glioma cell	-	Rattus norvegicus	-
glioblastoma cell	-	Rattus norvegicus	-
Neuro-2a cell	-	Mus musculus	-
neuron	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heme + AH2 + O2	-	Mus musculus	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	-	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide, overview	Mus musculus	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	statin-induced heme oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide, overview	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?

Synonyms

Synonyms	Comment	Organism
heme oxygenase-1	-	Mus musculus
heme oxygenase-1	-	Rattus norvegicus
HO-1	-	Mus musculus
HO-1	-	Rattus norvegicus

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Release 2023.1 (January 2023)