Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical vein endothelial cell | HUVECs | Homo sapiens | - |
vascular endothelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells, overview. The induction is abolished by knockout of Nrf2 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | 4-hydroxy hexenal stimulates expression of the antioxidant enzyme HO-1 through the activation of Nrf2 in vascular endothelial cells resulting in prevention of oxidative stress-induced cytotoxicity, this may represent a possible mechanism to partly explain the cardioprotective effects of n-3 polyunsaturated fatty acids | Homo sapiens |