Literature summary for 1.14.14.18 extracted from

Roman, G.; Rahman, M.; Vukomanovic, D.; Jia, Z.; Nakatsu, K.; Szarek, W.
Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone (2010), Chem. Biol. Drug Des., 75, 68-90.

Search for more literature for 1.14.14.18

Crystallization (Commentary)

Crystallization (Comment)	Organism
truncated, soluble hHO-1 variant, consisting of 233 amino acids, in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone, sitting-drop vapor diffusion, room temperature, 0.412 mM heme-HO-1 complex in 20 mM potassium phosphate is mixed with inhibitor in a 1:3 molar ratio, the reservoir solution contains100 mM HEPES, pH 7.5, 2.00-2.28 M ammonium sulfate, and 0.8-1.1% 1,6-hexanediol, X-ray diffraction structure determination and analysis	Rattus norvegicus

Crystallization (Comment)

Organism

truncated, soluble hHO-1 variant, consisting of 233 amino acids, in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone, sitting-drop vapor diffusion, room temperature, 0.412 mM heme-HO-1 complex in 20 mM potassium phosphate is mixed with inhibitor in a 1:3 molar ratio, the reservoir solution contains100 mM HEPES, pH 7.5, 2.00-2.28 M ammonium sulfate, and 0.8-1.1% 1,6-hexanediol, X-ray diffraction structure determination and analysis

Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism
(R,S)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol	-	Rattus norvegicus
(R,S)-1-(4,5-diphenyl-1H-imidazol-1-yl)-4-phenyl-2-butanol	-	Rattus norvegicus
(R,S)-4-phenyl-1-(1H-1,2,3-triazol-1-yl)-2-butanol	-	Rattus norvegicus
(R,S)-4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol	-	Rattus norvegicus
(R,S)-4-phenyl-1-(1H-tetrazol-1-yl)-2-butanol	-	Rattus norvegicus
(R,S)-4-phenyl-1-(2H-tetrazol-2-yl)-2-butanol	-	Rattus norvegicus
(R,S)-4-phenyl-1-(4-phenyl-1H-imidazol-1-yl)-2-butanol	-	Rattus norvegicus
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,3-triazole	-	Rattus norvegicus
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole	-	Rattus norvegicus
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-tetrazole	-	Rattus norvegicus
1-((2-phenylethyl)-1,3-dioxolan-2-yl)methyl-1H-imidazole	-	Rattus norvegicus
1-((2-phenylethyl-1,3-dioxolan-2-yl)methyl)-4,5-diphenyl-1H-imidazole	-	Rattus norvegicus
1-((2-phenylethyl-1,3-dioxolan-2-yl)methyl)-4-phenyl-1H-imidazole	-	Rattus norvegicus
1-(1H-benzimidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(1H-benzotriazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(2-methyl-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(2-methylsulfonyl-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(2-methylthio-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(2-nitro-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(2H-benzotriazol-2-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3,5-dibromo-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3-methylsulfonyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3-methylthio-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3-nitro-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(3-phenyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(4,5-dichloro-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(4,5-dicyano-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(4,5-diphenyl-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(4-bromo-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(4-nitro-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-bromo-1H-imidazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylsulfonyl-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylsulfonyl-1H-tetrazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylsulfonyl-2H-tetrazol-2-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylthio-1H-1,2,4-triazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylthio-1H-tetrazol-1-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-(5-methylthio-2H-tetrazol-2-yl)-4-phenyl-2-butanone	-	Rattus norvegicus
1-bromo-4-phenyl-2-butanone	-	Rattus norvegicus
2-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-2H-1,2,3-triazole	-	Rattus norvegicus
2-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-2H-tetrazole	-	Rattus norvegicus
2-methylthio-1H-imidazole	-	Rattus norvegicus
3,5-dibromo-1H-1,2,4-triazole	-	Rattus norvegicus
3,5-diphenyl-1H-1,2,4-triazole	-	Rattus norvegicus
3-phenyl-1H-1,2,4-triazole	-	Rattus norvegicus
4-phenyl-1-(1H-1,2,3-triazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone	the inhibitor binds at the distal pocket through the coordination of heme iron by the N4 in the triazole mpiety, whereas the phenyl group is stabilized by hydrophobic interactions from residues within the binding pocket, binding structure, modelling, overview	Rattus norvegicus
4-phenyl-1-(1H-pyrazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(1H-tetrazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(2-phenyl-1H-imidazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(2H-1,2,3-triazol-2-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(2H-tetrazol-2-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(4-phenyl-1H-imidazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(5-phenyl-1H-tetrazol-1-yl)-2-butanone	-	Rattus norvegicus
4-phenyl-1-(5-phenyl-2H-tetrazol-2-yl)-2-butanone	-	Rattus norvegicus
azalanstat	-	Rattus norvegicus
dimethyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-4,5-dicarboxylate	-	Rattus norvegicus
ethyl (1-(2-oxo-4-phenylbutyl)-1H-tetrazol-5-yl)acetate	-	Rattus norvegicus
ethyl (2-(2-oxo-4-phenylbutyl)-2H-tetrazol-5-yl)acetate	-	Rattus norvegicus
ethyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-2-carboxylate	-	Rattus norvegicus
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-1,2,4-triazole-3-carboxylate	-	Rattus norvegicus
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-1,2,4-triazole-5-carboxylate	-	Rattus norvegicus
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-4-carboxylate	-	Rattus norvegicus
methyl 1-(2-oxo-4-phenylbut-1-yl)-1H-imidazole-5-carboxylate	-	Rattus norvegicus
additional information	design and synthesis, and inhibitory potency of a series of 2-oxy-substituted 1-azolyl-4-phenylbutanes, inhibition of heme oxygenase-1 and heme oxygenase-2, overview	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-
Rattus norvegicus Sprague-Dawley	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
spleen	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	heme oxygenase activity in rat spleen and brain microsomal fractions is determined by the quantitation of CO formed from the degradation of methemalbumin, i.e. heme complexed with albumin	Rattus norvegicus	?	-	?
additional information	heme oxygenase activity in rat spleen and brain microsomal fractions is determined by the quantitation of CO formed from the degradation of methemalbumin, i.e. heme complexed with albumin	Rattus norvegicus Sprague-Dawley	?	-	?

Synonyms

Synonyms	Comment	Organism
heme oxygenase-1	-	Rattus norvegicus
heme oxygenase-2	-	Rattus norvegicus
HO-1	-	Rattus norvegicus
HO-2	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus