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Literature summary for 1.14.14.19 extracted from

  • Sheets, J.J.; Zuber, M.X.; McCarthy, J.L.; Vickery, L.E.; Waterman, M.R.
    Discriminatory inhibition of adrenocortical 17alpha-hydroxylase activity by inhibitors of cholesterol side chain cleavage cytochrome P-450 (1985), Arch. Biochem. Biophys., 242, 297-305.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
22-Amino-23,24-bisnor-5-cholen-3beta-ol type II competitive inhibitor Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome endoplasmic reticulum Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+ heme Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + AH2 + O2 Bos taurus
-
17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Bos taurus
-
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + AH2 + O2
-
Bos taurus 17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Bos taurus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000029
-
22-Amino-23,24-bisnor-5-cholen-3beta-ol 17alpha-hydroxylase activity Bos taurus