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Literature summary for 1.14.14.19 extracted from
- Studies on cytochrome P-450 (P-450 17alpha,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5 (1985), Biochim. Biophys. Acta, 833, 151-160.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 | above pH 6.3-6.5 stimulates 17alpha-hydrolase and c17,20-lyase activity | Cavia porcellus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 | supresses 17alpha-hydrolase and C17,20-lyase activity below pH 6.3-6.5 | Cavia porcellus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Cavia porcellus | - |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.1 | - |
both 17alpha-hydroxylation and C17,20-lyase actiivty | Cavia porcellus |
| 6.6 | - |
C17,20-lyase activity after addition of cytochrome b5 | Cavia porcellus |
| 7 | - |
17alpha-hydroxylation after addition of cytochrome b5 | Cavia porcellus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Cavia porcellus |  |
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