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Literature summary for 1.14.14.19 extracted from
- Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2 (2005), Epilepsia, 46, 444-448.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not activating: antiepileptic drugs valproic acid, carbamazepine, topiramate, lamotrigine | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | women with epilepsy have a higher incidence of polycystronic ovary syndrome. At concentrations normally used in antiepileptic drug therapy, the drugs valproic acid, carbamazepine, topiramate, lamotrigine do not influence 17alpha-hydroxylase/17,20-lyase and 3beta-hydroxysteroid dehydrogenase type 2 activities | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibitory: antiepileptic drugs valproic acid, carbamazepine, topiramate, lamotrigine | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant enzyme | - |
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