Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.19 extracted from

  • Beshay, V.E.; Havelock, J.C.; Sirianni, R.; Ye, P.; Suzuki, T.; Rainey, W.E.; Carr, B.R.
    The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model (2007), J. Clin. Endocrinol. Metab., 92, 4802-4809.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information reduced c-fos expression in polycystic ovary syndrome leads to reduced enzyme suppression, increased expression and activity resulting in increased androgen production Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information c-fos is an activator protein-1 transcription factor involved in the regulation of CYP17 expression in theca cells, tetradecanoylphorbol acetate increases c-fos 37fold leading to complete suppression of the enzyme, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is required for androgen production, genetic regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
Homo sapiens
-
theca folliculi
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is required for androgen production, genetic regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase
-
Homo sapiens
17alpha-hydroxylase 17,20 lyase
-
Homo sapiens
CYP17
-
Homo sapiens