Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for inhibitor design | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
CYP17, expression in Escherichia coli, co-expression with NADPH-P450 reductase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-(benzo[b]thiophen-5-yl)phenyl)methanol | 2% inhibition at 200 nM and 39% inhibition at 0.002 mM | Homo sapiens | |
1-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)phenyl)-methyl)-1H-imidazole | 19% inhibition at 200 nM and 74% inhibition at 0.002 mM | Homo sapiens | |
1-(1-(4-(benzo[b]thiophen-5-yl)phenyl)propyl)-1H-imidazole | 21% inhibition at 200 nM and 75% inhibition at 0.002 mM | Homo sapiens | |
1-(1-(4-(naphthalen-2-yl)phenyl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(3-(4-(6-(tert-butyldimethylsilyloxy)naphthalen-2-yl)phenyl)pentan-3-yl)-1H-imidazole | - |
Homo sapiens | |
1-(4-(6-methoxynaphthalen-2-yl)phenyl)propan-1-ol | 7% inhibition at 200 nM and 43% inhibition at 0.002 mM | Homo sapiens | |
1-(4-(benzofuran-5-yl)benzyl)-1H-imidazole | no inhibition at 200 nM and 21% inhibition at 0.002 mM | Homo sapiens | |
4-(8-(1-(1H-imidazol-1-yl)propyl)quinolin-5-yl)phenol | 17% inhibition at 200 nM and 71% inhibition at 0.002 mM | Homo sapiens | |
4-(benzo[b]thiophen-5-yl)benzaldehyde | 7% inhibition at 200 nM and 40% inhibition at 0.002 mM | Homo sapiens | |
5-(4-(1-(1H-imidazol-1-yl)propyl)phenyl)-1H-indole | 5% inhibition at 200 nM and 27% inhibition at 0.002 mM | Homo sapiens | |
5-(4-(1H-imidazol-1-ylmethyl)phenyl)-1H-indole | 5% inhibition at 200 nM and 39% inhibition at 0.002 mM | Homo sapiens | |
6-(4-(1H-imidazol-1-ylmethyl)phenyl)benzo[d]thiazole | no inhibition at 200 nM and 17% inhibition at 0.002 mM | Homo sapiens | |
6-(4-(3-(1H-imidazol-1-yl)pentan-3-yl)phenyl)naphthalen-2-ol | 16% inhibition at 200 nM and 74% inhibition at 0.002 mM | Homo sapiens | |
abiraterone | - |
Homo sapiens | |
ketoconazole | is a weak inhibitor of CYP17, 29% inhibition at 0.0002 mM | Homo sapiens | |
additional information | CYP17 inhibitory activities, docking and molecular modelling of inhibitors, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase-17,20-lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.667 | - |
- |
Homo sapiens | 1-(1-(4-(benzo[b]thiophen-5-yl)phenyl)propyl)-1H-imidazole |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP17 is the key enzyme for the biosynthesis of androgens | Homo sapiens |