Literature summary for 1.14.14.19 extracted from

Ahmed, S.; Shahid, I.; Dhanani, S.; Owen, C.P.
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)) (2009), Bioorg. Med. Chem. Lett., 19, 4698-4701.

Search for more literature for 1.14.14.19

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(4-chlorobenzyl)-1H-imidazole	-	Homo sapiens
1-(4-fluorobenzyl)-1H-imidazole	-	Homo sapiens
1-(4-methylbenzyl)-1H-imidazole	-	Homo sapiens
1-(4-nitrobenzyl)-1H-imidazole	-	Homo sapiens
1-[4-(1H-imidazol-1-ylmethyl)phenyl]methanimine	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-bromobenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-chlorobenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-iodobenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-methoxybenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-methylbenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl 4-nitrobenzenesulfonate	-	Homo sapiens
4-(1H-imidazol-1-ylmethyl)phenyl benzenesulfonate	-	Homo sapiens
4-hydroxybenzyl imidazole	-	Homo sapiens
abiraterone	-	Homo sapiens
ketoconazole	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
progesterone + 2 NADPH + 2 H+ + 2 O2	Homo sapiens	reaction via 17alpha-hydroxyprogesterone	androstenedione + acetate + 2 NADP+ + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
progesterone + 2 NADPH + 2 H+ + 2 O2	reaction via 17alpha-hydroxyprogesterone	Homo sapiens	androstenedione + acetate + 2 NADP+ + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
17alpha-hydroxylase	-	Homo sapiens
17alpha-hydroxylase/17,20-lyase	-	Homo sapiens
17alpha-OHase	-	Homo sapiens
P450-17alpha	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)