Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-3-[3-hydroxy-4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]phenyl]prop-2-enoic acid | 41.34% inhibition at 0.01 mM | Homo sapiens | |
(2Z)-3-[4-methoxy-3-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]phenyl]prop-2-enoic acid | 43.27% inhibition at 0.01 mM | Homo sapiens | |
(2Z)-3-[4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]phenyl]prop-2-enoic acid | 45.5% inhibition at 0.01 mM | Homo sapiens | |
17-((1-(2-(trifluoromethyl)-1H-benzimidazol-5-yl)imino)ethyl)-5-androsten-3beta-ol | 78.61% inhibition at 0.01 mM | Homo sapiens | |
17-((1-(6-methoxybenzothiazol-2-yl)imino)ethyl)-5-androsten-3beta-ol | 81.99% inhibition at 0.01 mM | Homo sapiens | |
17-(1-(n-hexylamino)-1-hydroxyethyl)-5-androsten-3beta-ol | 62.52% inhibition at 0.01 mM | Homo sapiens | |
2-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzamide | 39.38% inhibition at 0.01 mM | Homo sapiens | |
3,5-dihydroxy-4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]benzoic acid | 83.21% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)-3-methoxybenzoic acid | 43.34% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)-N-(4-methylpyrimidin-2-yl)benzenesulfonamide | 56.23% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)-N-(isoxazol-3-yl)benzenesulfonamide | 81.78% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)-N-(pyrimidin-2-yl)benzenesulfonamide | 16.27% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzenesulfonamide | 57.1% inhibition at 0.01 mM; 78.84% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzenesulfonic acid | 8.37% inhibition at 0.01 mM | Homo sapiens | |
4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzoic acid | 49.21% inhibition at 0.01 mM | Homo sapiens | |
abiraterone | 85.38% inhibition at 0.01 mM | Homo sapiens | |
N-(4,6-dimethylpyrimidin-2-yl)-4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzene sulfonamide | 48.37% inhibition at 0.01 mM | Homo sapiens | |
N-(4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)phenyl)acetamide | 40.02% inhibition at 0.01 mM | Homo sapiens | |
sulfamerazine | 53.44% inhibition at 0.01 mM | Homo sapiens | |
sulfamethazine | 49.34% inhibition at 0.01 mM | Homo sapiens | |
sulfamethoxazole | 55.23% inhibition at 0.01 mM | Homo sapiens | |
TOK-001 | also named galeterone | Homo sapiens | |
VN/85-1 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase-C17,20-lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000072 | - |
at pH 7.4 and 37°C | Homo sapiens | abiraterone | |
0.00129 | - |
at pH 7.4 and 37°C | Homo sapiens | 3,5-dihydroxy-4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]benzoic acid | |
0.00211 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)-N-(isoxazol-3-yl)benzenesulfonamide | |
0.00238 | - |
at pH 7.4 and 37°C | Homo sapiens | 17-((1-(6-methoxybenzothiazol-2-yl)imino)ethyl)-5-androsten-3beta-ol | |
0.00311 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzenesulfonamide | |
0.00329 | - |
at pH 7.4 and 37°C | Homo sapiens | 17-((1-(2-(trifluoromethyl)-1H-benzimidazol-5-yl)imino)ethyl)-5-androsten-3beta-ol | |
0.01859 | - |
at pH 7.4 and 37°C | Homo sapiens | 17-(1-(n-hexylamino)-1-hydroxyethyl)-5-androsten-3beta-ol | |
0.0198 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzenesulfonamide | |
0.0222 | - |
at pH 7.4 and 37°C | Homo sapiens | (2Z)-3-[3-hydroxy-4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]phenyl]prop-2-enoic acid | |
0.0247 | - |
at pH 7.4 and 37°C | Homo sapiens | (2Z)-3-[4-[([[(3alpha)-3-methyl-20-oxopregn-5-en-3-yl]oxy]carbonyl)oxy]phenyl]prop-2-enoic acid | |
0.0268 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(4,6-dimethylpyrimidin-2-yl)-4-((1-(5-androsten-3beta-ol-17-yl)ethylidene)amino)benzene sulfonamide | |
0.0342 | - |
at pH 7.4 and 37°C | Homo sapiens | sulfamerazine |