BRENDA - Enzyme Database show
show all sequences of 1.14.14.25

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimers disease

Solomon, A.; Leoni, V.; Kivipelto, M.; Besga, A.; Oksengard, A.R.; Julin, P.; Svensson, L.; Wahlund, L.O.; Andreasen, N.; Winblad, B.; Soininen, H.; Bjoerkhem, I.; Neurosci. Lett. 462, 89-93 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
abnormal expression of cholesterol 24S-hydroxylase in astrocytes in Alzheimer's disease, which may limit the usefulness of the plasma marker 24S-hydroxycholesterol in this specific disease
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
astrocyte
-
Homo sapiens
-
brain
-
Homo sapiens
-
glial cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
705920
Homo sapiens
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
abnormal expression of cholesterol 24S-hydroxylase in astrocytes in Alzheimer's disease, which may limit the usefulness of the plasma marker 24S-hydroxycholesterol in this specific disease
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
astrocyte
-
Homo sapiens
-
brain
-
Homo sapiens
-
glial cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
705920
Homo sapiens
(24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.25
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735877
Boussicault
CYP46A1, the rate-limiting enz ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Brain
139
953-970
2016
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736502
Anderson
Cholesterol hydroxylase CYP46A ...
Homo sapiens
J. Biol. Chem.
291
11876-81186
2016
2
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736072
Uto
Imidazo[1,2-a]pyridines as cho ...
Homo sapiens
Expert Opin. Ther. Pat.
25
373-377
2015
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735602
Fourgeux
In vivo consequences of choles ...
Rattus norvegicus, Rattus norvegicus Wistar
Biochem. Biophys. Res. Commun.
446
775-781
2014
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728617
Maioli
Is it possible to improve memo ...
Homo sapiens
PLoS ONE
8
e68534
2013
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712869
Liao
Quantification of cholesterol- ...
Homo sapiens
J. Proteome Res.
10
241-248
2011
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727298
Fourgeux
24S-hydroxycholesterol and cho ...
Homo sapiens
Chem. Phys. Lipids
164
496-499
2011
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705008
Shafaati
The antifungal drug voriconazo ...
Homo sapiens, Mus musculus
J. Lipid Res.
51
318-323
2010
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705825
Hudry
Adeno-associated Virus gene th ...
Homo sapiens, Mus musculus, Mus musculus APP23
Mol. Ther.
18
44-53
2010
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2
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711641
Cartagena
24S-hydroxycholesterol effects ...
Homo sapiens
Brain Res.
1319
1-12
2010
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1
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712120
Smiljanic
Brain injury induces cholester ...
Rattus norvegicus, Rattus norvegicus Wistar
Histochem. Cell Biol.
134
159-169
2010
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167
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712816
Tian
Increased expression of choles ...
Homo sapiens
J. Neurochem.
113
978-989
2010
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1
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1
1
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695874
Mast
Combined use of mass spectrome ...
Homo sapiens
Arch. Biochem. Biophys.
483
81-89
2009
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698342
Fu
Cholesterol 24-hydroxylase (CY ...
Homo sapiens
Int. J. Geriatr. Psychiatry
24
921-926
2009
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1
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701715
Russell
Cholesterol 24-hydroxylase: an ...
Bos taurus, Canis lupus familiaris, Cavia porcellus, Danio rerio, Equus caballus, Equus sp., Gallus gallus, Homo sapiens, Macaca mulatta, Mus musculus, Ornithorhynchus anatinus, Oryctolagus cuniculus, Pan troglodytes, Rattus norvegicus, Xenopus laevis
Annu. Rev. Biochem.
78
1017-1040
2009
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17
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11
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3
3
2
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702028
Shafaati
Transcriptional regulation of ...
Homo sapiens, Mus musculus, Mus musculus C57B6-J
Biochem. Biophys. Res. Commun.
378
689-694
2009
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703580
Koelsch
CYP46A1 variants influence Alz ...
Homo sapiens
Eur. Psychiatry
24
183-190
2009
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1
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704109
Fourgeux
Primary open angle glaucoma: A ...
Homo sapiens
Invest. Ophthalmol. Vis. Sci.
50
5712-5717
2009
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705920
Solomon
Plasma levels of 24S-hydroxych ...
Homo sapiens
Neurosci. Lett.
462
89-93
2009
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706536
Halford
Reduction of cholesterol synth ...
Mus musculus
Proc. Natl. Acad. Sci. USA
106
3502-3506
2009
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687987
Ramirez
Neuronal expression and subcel ...
Mus musculus
J. Comp. Neurol.
507
1676-1693
2008
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688555
Cartagena
Cortical injury increases chol ...
Rattus norvegicus
J. Neurotrauma
25
1087-1098
2008
1
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689814
Mast
Crystal structures of substrat ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
105
9546-9551
2008
1
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6
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705612
Martin
Cholesterol loss enhances TrkB ...
Mus musculus, Rattus norvegicus
Mol. Biol. Cell
19
2101-2112
2008
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684856
Famer
Regulation of alpha- and beta- ...
Homo sapiens
Biochem. Biophys. Res. Commun.
359
46-50
2007
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