BRENDA - Enzyme Database show
show all sequences of 1.14.14.32

Insulin inhibits adrenal 17,20-lyase activity in man

Nestler, J.E.; McClanahan, M.A.; Clore, J.N.; Blackard, W.G.; J. Clin. Endocrinol. 74, 362-367 (1992)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Insulin
acute and selective
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
17alpha-Hydroxypregnenolone
-
5126
Homo sapiens
Dehydroepiandrosterone + acetaldehyde
DHEA
5126
Homo sapiens
-
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5126
Homo sapiens
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
androstenedione
5126
Homo sapiens
-
additional information
acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)
5126
Homo sapiens
?
-
-
-
-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Insulin
acute and selective
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
17alpha-Hydroxypregnenolone
-
5126
Homo sapiens
Dehydroepiandrosterone + acetaldehyde
DHEA
5126
Homo sapiens
-
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
5126
Homo sapiens
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
androstenedione
5126
Homo sapiens
-
additional information
acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)
5126
Homo sapiens
?
-
-
-
-
Other publictions for EC 1.14.14.32
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745365
Gonzalez
Kinetic processivity of the t ...
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J. Biol. Chem.
292
13168-13185
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11
11
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Modulation of expression of 17 ...
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1
1
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732996
Szabo
Determination of 17alpha-hydro ...
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Acta Biol. Hung.
66
41-51
2015
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5
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734569
Yoshimoto
The diverse chemistry of cytoc ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
151
52-65
2015
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7
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739432
Simonov
Mechanistic scrutiny identifie ...
Homo sapiens
PLoS ONE
10
e0141252
2015
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1
1
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745754
Toren
Anticancer activity of a nove ...
Homo sapiens
Mol. Cancer Ther.
14
59-69
2015
-
1
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1
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1
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726886
Khatri
Active site proton delivery an ...
Homo sapiens
Biochem. Biophys. Res. Commun.
443
179-184
2014
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1
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735283
Kuzikov
Novel oxazolinyl derivatives o ...
Homo sapiens
Steroids
88
66-71
2014
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4
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2
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2
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737703
Mak
Resonance Raman spectroscopy r ...
Homo sapiens
Biochemistry
53
90-100
2014
-
-
-
1
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1
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727424
Kovacs
An efficient approach to novel ...
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Eur. J. Med. Chem.
70
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2013
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6
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728827
Roelofs
The relevance of chemical inte ...
Homo sapiens, Sus scrofa
Toxicol. Appl. Pharmacol.
268
309-317
2013
-
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-
13
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2
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2
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4
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2
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2
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714275
Shumyantseva
Screening of potential substra ...
Homo sapiens
Biochemistry (Moscow) Suppl. Ser. B
57
402-409
2011
-
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4
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1
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2
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2
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4
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2
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4
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4
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714352
Gilep
At the crossroads of steroid h ...
Bison bison, Bos taurus, Capra hircus, Cavia porcellus, Equus caballus, Felis catus, Homo sapiens, Mus musculus, Ovis aries, Pan troglodytes, Papio sp., Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1814
200-209
2011
13
-
13
-
14
-
9
-
26
-
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37
-
14
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1
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16
13
-
46
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1
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13
-
13
1
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14
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9
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26
-
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37
-
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1
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-
16
13
-
46
-
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-
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715857
Stefanachi
Design, synthesis, and biologi ...
Homo sapiens
J. Med. Chem.
54
1613-1625
2011
-
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1
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20
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1
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20
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1
1
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715984
Manca
Immunohistochemical localisati ...
Rattus norvegicus
J. Neuroendocrinol.
23
444-449
2011
-
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1
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1
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3
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1
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703775
Chen
Cloning and expression of P450 ...
Cynoglossus semilaevis
Fish Physiol. Biochem.
36
1001-1012
2010
-
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14
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11
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2
1
1
2
-
-
703945
Rosa
Clinical, genetic and function ...
Homo sapiens
Horm. Res. Paediatr.
73
198-204
2010
-
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1
-
4
-
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2
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2
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1
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2
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1
1
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-
705389
Zhang
Seasonal changes in spermatoge ...
Spermophilus dauricus
J. Reprod. Dev.
56
297-302
2010
-
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1
1
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706778
Ivanyi
Synthesis of regioisomeric 17b ...
Rattus norvegicus
Steroids
75
450-456
2010
-
1
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-
24
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2
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1
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4
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1
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4
24
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1
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706819
Neto
Cellular localization of andro ...
Equus sp.
Theriogenology
74
393-401
2010
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2
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6
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6
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1
1
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-
713129
Frank
-
Intramolecular approach to som ...
Rattus norvegicus
New J. Chem.
34
2671-2681
2010
-
-
-
-
-
-
2
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1
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1
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1
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2
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-
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2
2
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1
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1
-
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-
692093
Nguyen
The developmental increase in ...
Macaca mulatta
Endocrinology
150
1748-1756
2009
1
-
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1
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4
-
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702581
Ahmed
Synthesis and biochemical eval ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
19
4698-4701
2009
-
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10
-
1
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2
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2
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1
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10
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