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Literature summary for 1.14.14.32 extracted from

  • Simonov, A.N.; Holien, J.K.; Yeung, J.C.; Nguyen, A.D.; Corbin, C.J.; Zheng, J.; Kuznetsov, V.L.; Auchus, R.J.; Conley, A.J.; Bond, A.M.; Parker, M.W.; Rodgers, R.J.; Martin, L.L.
    Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17 (CYP17A1, P450 17A1) (2015), PLoS ONE, 10, e0141252.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P05093 cf. EC 1.14.14.19
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Synonyms

Synonyms Comment Organism
cytochrome P450c17
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 Homo sapiens

General Information

General Information Comment Organism
physiological function within living cells there are close interactions between cytochrome P450c17 and cytochrome b5. Residues E48 and E49 in cytochrome b5 are essential for activity, specific protein-protein interactions take place in a lipid membrane. The wild type cytochrome b5, but not a mutated, E48G/E49G cyt b5, alters the kinetics of electron transfer between the electrode and the P450c17 Homo sapiens