Literature summary for 1.14.14.47 extracted from

Holden, J.K.; Lewis, M.C.; Cinelli, M.A.; Abdullatif, Z.; Pensa, A.V.; Silverman, R.B.; Poulos, T.L.
Targeting bacterial nitric oxide synthase with aminoquinoline-based inhibitors (2016), Biochemistry, 55, 5587-5594.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Bacillus subtilis

Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-tye and mutant I208V, in complex with inhibitors	Bacillus subtilis

Protein Variants

Protein Variants	Comment	Organism
I208V	crystallization and inhibition data	Bacillus subtilis

Inhibitors

Inhibitors	Comment	Organism	Structure
4-methylquinolin-2-amine	among the most potent aminoquinoline inhibitors tested, KS value 0.00080 mM	Bacillus subtilis
quinolin-2-amine	among the most potent aminoquinoline inhibitors tested, KS value 0.00125 mM	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	O34453	-	-
Bacillus subtilis 168	O34453	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0273	-	wild-type, pH not specified in the publication, temperature not specified in the publication	Bacillus subtilis	quinolin-2-amine
0.0366	-	wild-type, pH not specified in the publication, temperature not specified in the publication	Bacillus subtilis	4-methylquinolin-2-amine
0.0533	-	mutant I208V, pH not specified in the publication, temperature not specified in the publication	Bacillus subtilis	4-methylquinolin-2-amine
0.0639	-	mutant I208V, pH not specified in the publication, temperature not specified in the publication	Bacillus subtilis	quinolin-2-amine

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Release 2023.1 (January 2023)