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Literature summary for 1.14.14.55 extracted from

  • Zhao, X.J.; Yokoyama, H.; Chiba, K.; Wanwimolruk, S.; Ishizaki, T.
    Identification of human cytochrome P450 isoforms involved in the hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450 (1996), J. Pharmacol. Exp. Ther., 279, 1327-1334.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of CYP3A4 in human B lymphoblastoid cell line AHH-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
anti-CYP2C antibodies inhibition of 20% Homo sapiens
anti-CYP3A4 antibodies inhibition of 72% Homo sapiens
ketoconazole maximum inhibition of 90% at 0.0005 mM Homo sapiens
S-mephenytoin maximum inhibition of 74% at 0.12 mM Homo sapiens
troleandomycin maximum inhibition of 70% at 0.08 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.046
-
 Quinine recombinant CYP2C19 Homo sapiens
0.106
-
 Quinine between 0.08 mM and 0.145 mM in 10 different human livers Homo sapiens
0.114
-
 Quinine recombinant CYP3A4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
quinine + NADPH + O2
-
 Homo sapiens 3-hydroxyquinine + NADP+ + H2O
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00327
-
 Quinine recombinant CYP2C19 Homo sapiens
0.125
-
 Quinine recombinant CYP3A4 Homo sapiens