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Literature summary for 1.14.14.55 extracted from

  • Zhao, X.J.; Kawashiro, T.; Ishizaki, T.
    Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways (1997), Drug Metab. Dispos., 26, 188-191.
    View publication on PubMed
Search for more literature for 1.14.14.55

Inhibitors

Inhibitors Comment Organism Structure
etoposide maximum inhibition of quinine 3-hydroxylation of 60% at 0.1 mM Homo sapiens
ketoconazole maximum inhibition of 90% at 0.001 mM Homo sapiens
Quinine maximum inhibition of etoposide 3'-demethylation of 52% at 0.1 mM Homo sapiens
troleandomycin maximum inhibition of 80% at 0.1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
etoposide + NADPH + O2
-
 Homo sapiens 3'-demethyletoposide + NADP+ + H2O
-
 ?
quinine + NADPH + O2
-
 Homo sapiens 3-hydroxyquinine + NADP+ + H2O
-
 ?