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Literature summary for 1.14.14.55 extracted from
- The in vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes (1997), J. Pharmacol. Exp. Ther., 283, 1168-1176.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| alpha-naphthoflavone | - |
Homo sapiens |  |
| alpha-naphthoflavone | - |
Canis lupus familiaris | |
| diazepam | - |
Homo sapiens | |
| diazepam | - |
Canis lupus familiaris | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-naphthoflavone | - |
Mus musculus | |
| alpha-naphthoflavone | - |
Rattus norvegicus | |
| anti-CYP3A4 antibodies | inhibition of 92% | Canis lupus familiaris | |
| anti-CYP3A4 antibodies | - |
Homo sapiens | |
| anti-CYP3A4 antibodies | inhibition of 96% | Mus musculus | |
| anti-CYP3A4 antibodies | inhibition of 84% | Rattus norvegicus | |
| Chloroquin | - |
Canis lupus familiaris | |
| Chloroquin | - |
Rattus norvegicus | |
| diazepam | - |
Mus musculus | |
| diazepam | - |
Rattus norvegicus | |
| doxycyclin | - |
Canis lupus familiaris | |
| doxycyclin | - |
Homo sapiens | |
| doxycyclin | - |
Rattus norvegicus | |
| ketoconazole | maximum inhibition of 88% | Canis lupus familiaris | |
| ketoconazole | maximum inhibition of 90% | Homo sapiens | |
| ketoconazole | maximum inhibition of 94% | Mus musculus | |
| ketoconazole | maximum inhibition of 91% | Rattus norvegicus | |
| p-nitrophenol | inhibition observed but not quantified | Homo sapiens | |
| p-nitrophenol | inhibits more than 75% at 10 mM | Mus musculus | |
| primaquine | - |
Canis lupus familiaris | |
| primaquine | - |
Homo sapiens | |
| primaquine | - |
Rattus norvegicus | |
| S-mephenytoin | - |
Homo sapiens | |
| S-mephenytoin | inhibits more than 70% at 0.5 mM | Mus musculus | |
| sulfaphenazole | inhibits more than 50% at 0.1 mM | Mus musculus | |
| tetracyclin | - |
Canis lupus familiaris | |
| tetracyclin | - |
Homo sapiens | |
| tetracyclin | - |
Rattus norvegicus | |
| troleandomycin | maximum inhibition of 93% | Canis lupus familiaris | |
| troleandomycin | maximum inhibition of 70% | Homo sapiens | |
| troleandomycin | maximum inhibition of 85% | Mus musculus | |
| troleandomycin | maximum inhibition of 66% | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0227 | - |
Quinine | - |
Rattus norvegicus | |
| 0.0297 | - |
Quinine | - |
Mus musculus | |
| 0.105 | - |
Quinine | - |
Homo sapiens | |
| 0.138 | - |
Quinine | - |
Canis lupus familiaris | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Canis lupus familiaris | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
dog | - |
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinine + NADPH + O2 | - |
Mus musculus | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
| quinine + NADPH + O2 | - |
Homo sapiens | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
| quinine + NADPH + O2 | - |
Rattus norvegicus | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
| quinine + NADPH + O2 | - |
Canis lupus familiaris | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
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