Cloned (Comment) | Organism |
---|---|
genes CYP3A5 and CYP3A4, DNA sequence determination, genotyping of two different human populations revealing the CYP3A5 and the CYP3A4 genotypes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A6986AG | single nucleotide polymorphism responsible for different CYP3A genotypes, CYP3A5 allele and genotype frequency in the populations, overview | Homo sapiens |
additional information | the CYP3A5 genotype has significant effect on quinine 3-hydroxylation in black Tanzanians, who have lower total CYP3A activity compared to a population of Swedish caucasians, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + NADPH + O2 | Homo sapiens | quinine is used for treatment of severe forms of Plasmodium falciparum malaria, phenotyping of two different populations, overview | 3-hydroxyquinine + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + NADPH + O2 | - |
Homo sapiens | 3-hydroxyquinine + NADP+ + H2O | - |
? | |
quinine + NADPH + O2 | quinine is used for treatment of severe forms of Plasmodium falciparum malaria, phenotyping of two different populations, overview | Homo sapiens | 3-hydroxyquinine + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |