Literature summary for 1.14.14.56 extracted from

Miyazawa, M.; Shindo, M.; Shimada, T.
Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes (2001), Xenobiotica, 31, 713-723.

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Activating Compound

Activating Compound	Comment	Organism	Structure
dexamethasone	induces activity	Rattus norvegicus
pregnenolone 16alpha-carbonitrile	induces activity	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in insect cells	Homo sapiens
expression in insect cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
ketoconazole	significant inhibition	Homo sapiens
ketoconazole	significant inhibition	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.45	-	1,4-cineole	pH 7.4, 37°C	Homo sapiens
1.033	-	1,4-cineole	pH 7.4, 37°C, animals treated with pregnenolone 16alpha-carbonitrile	Rattus norvegicus
1.123	-	1,4-cineole	pH 7.4, 37°C, animals treated with dexamethasone	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Homo sapiens	2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Rattus norvegicus	2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Homo sapiens	2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2	-	Rattus norvegicus	2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP3A4	-	Homo sapiens

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Release 2023.1 (January 2023)