Literature summary for 1.14.14.72 extracted from

Henquet, M.G.L.; Prota, N.; van der Hooft, J.J.J.; Varbanova-Herde, M.; Hulzink, R.J.M.; de Vos, M.; Prins, M.; de Both, M.T.J.; Franssen, M.C.R.; Bouwmeester, H.; Jongsma, M.
Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes (2017), Plant J., 90, 1052-1063 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.011	-	drimenol	pH 7.5, 25°C	Persicaria hydropiper

Organism

Organism	UniProt	Comment	Textmining
Persicaria hydropiper	W0FKI0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
drimenol + [reduced NADPH-hemoprotein reductase] + O2	-	Persicaria hydropiper	drimendiol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
additional information	DOX1 catalyses the conversion from drimenol to drimendiol, and not the further oxidation into an aldehyde	Persicaria hydropiper	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 56149, calculated	Persicaria hydropiper

Synonyms

Synonyms	Comment	Organism
CYP76AJ1	-	Persicaria hydropiper
DOX1	-	Persicaria hydropiper
drimenol oxidase 1	-	Persicaria hydropiper

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	-	Persicaria hydropiper

General Information

General Information	Comment	Organism
physiological function	coexpression of drimenol synthase with drimenol oxidase DOX1 in yeast yields drimendiol, the 12-hydroxylation product of drimenol, as a major product, and cinnamolide. Upon coexpression of drimenol synthase with drimenol oxidase DOX1 in Nicotiana benthamiana leaves, drimenol is almost completely converted into cinnamolide and several additional drimenol derivatives are observed	Persicaria hydropiper

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Release 2023.1 (January 2023)