Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.73 extracted from

  • Rawden, H.; Kokwaro, G.; Ward, S.; Edwards, G.
    Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes (2000), Br. J. Clin. Pharmacol., 49, 313-322 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.73

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole 0.5-1 microM, 32% inhibition Homo sapiens
ritonavir 0.5-1 microM, 34% inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P08684
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP3A4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function flavin monoxygenases and cytochrome P450 reductase contribute about 30% and 70%, respectively, to albendazole S-oxide production in vitro. CYP3A4 is the mainly contributing cytochrome component Homo sapiens