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show all sequences of 1.14.14.73

Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

Rawden, H.; Kokwaro, G.; Ward, S.; Edwards, G.; Br. J. Clin. Pharmacol. 49, 313-322 (2000)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
ketoconazole
0.5-1 microM, 32% inhibition
Homo sapiens
ritonavir
0.5-1 microM, 34% inhibition
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P08684
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
744610
Homo sapiens
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ketoconazole
0.5-1 microM, 32% inhibition
Homo sapiens
ritonavir
0.5-1 microM, 34% inhibition
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
744610
Homo sapiens
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
flavin monoxygenases and cytochrome P450 reductase contribute about 30% and 70%, respectively, to albendazole S-oxide production in vitro. CYP3A4 is the mainly contributing cytochrome component
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
flavin monoxygenases and cytochrome P450 reductase contribute about 30% and 70%, respectively, to albendazole S-oxide production in vitro. CYP3A4 is the mainly contributing cytochrome component
Homo sapiens
Other publictions for EC 1.14.14.73
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744771
Gul
Microbial flavoprotein monoox ...
Rhodococcus jostii, Thermothelomyces thermophilus
Drug Metab. Dispos.
44
1270-1276
2016
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2
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2
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744049
Wu
CYP2J2 and CYP2C19 are the ma ...
Homo sapiens
Antimicrob. Agents Chemother.
57
5448-5456
2013
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1
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2
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744770
Lee
Identification of novel subst ...
Homo sapiens
Drug Metab. Dispos.
38
347-356
2010
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1
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1
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1
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1
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8
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744610
Rawden
Relative contribution of cyto ...
Homo sapiens
Br. J. Clin. Pharmacol.
49
313-322
2000
-
-
-
-
-
-
2
-
1
-
-
-
-
1
-
-
-
-
-
1
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1
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1
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1
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2
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1
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1
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1
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1
1
-
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-
744768
Moroni
Chiral sulfoxidation of alben ...
Rattus norvegicus
Drug Metab. Dispos.
23
160-165
1995
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-
-
-
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-
1
-
1
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1
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1
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1
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1
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1
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1
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1
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1
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1
1
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745602
Souhaili-El Amri
Albendazole sulfonation by ra ...
Rattus norvegicus
J. Pharmacol. Exp. Ther.
246
758-764
1988
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1
1
1
1
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746557
Souhaili El Amri
Sulphoxidation of albendazole ...
Sus scrofa
Xenobiotica
17
1159-1174
1987
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1
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