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Literature summary for 1.14.14.73 extracted from
- Sulphoxidation of albendazole by the FAD-containing and cytochrome p-450 dependent mono-oxygenases from pig liver microsomes (1987), Xenobiotica, 17, 1159-1174 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| albendazole + [reduced NADPH-hemoprotein reductase] + O2 | - |
Sus scrofa | albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | metabolism of albendazole to albendazole-sulfoxide by pig liver microsomes is dependent on both microsomal cytochrome P-450 and FAD-containing mono-oxygenase enzymes. the relative contributions of the two systems depend on the concentration of albendazole | Sus scrofa |
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